Udacity

Udacity’s proven playbook is globally scalable, addressing the widespread digital talent shortages that impact growth, productivity, and innovation. We collaborate with enterprises and highly motivated individuals to design a tailored talent transformation journey enabled by our Digital Competency Platform. Our exclusive content is co-created and continually refined with industry leaders. Each Udacity program is deeply focused—eliminating guesswork in selecting the right course. Projects go far beyond step-by-step guides, cultivating the critical thinking required for workplace relevance. Expert mentors unblock learning with personalized support, and verify complete mastery of competencies.

Querium

The platform provides individual lessons that employ The StepWise Virtual Tutor that uses A.I. technology that simulates an expert teacher or tutor and is available 24/7.

ViewsIQ

Dartmouth College

Real time capture of microscope video that is digitized, formatted and stored for AI and ML based use to enhance patient diagnosis.

Qrypt

An integrated quantum hardware and cryptographic solution for securing data. TRL 9

Arqit

Enables any device to download a lightweight software agent of less than 200 lines of code, which can create encryption keys in partnership with any other device. The keys are computationally secure, one-time use and zero trust. TRL: 9

ColdQuanta

When atoms are cooled to a few millionths of a degree above absolute zero, they take on quantum properties. Lasers are used to arrange the atoms, hold them in place, run computations on them, and read out the results. Quantum calculations, communications, and sensing are the result. This quantum technology can be used to solve some of the world’s most challenging problems.

Immunai

Drug discovery and development is complicated, time-consuming and costly. Immunai’s computational approach and experimental apparatus is focused on understanding core pathways and mechanisms within each immune cell compartment, and the intersection of these compartments to comprehensively examine disease etiology, and how to reverse it. MIT Startup Exchange / Harvard

Invictus BCI

Using machine learning and neuroscience, Invictus BCI has created an affordable prosthetic control interface that has a greater movement capability and is more comfortable. Developer of a brain-controlled interface technology intended to create prosthetic control interfaces that can restore near natural functionality. The company's technology leverages new advances in machine learning and neuroscience to create a prosthetic control interface that has more intuitive control, greater movement capability, enabling patients to get access to greater comfort all while being far less expensive. TE

Innerworld

Vanderbilt University

Innerworld offers a safe, immersive virtual platform designed to enhance patient engagement and facilitate the exploration of emotions and behaviors. Through our interactive therapy world, users learn life-changing Cognitive Behavioral Immersion™ (CBI) tools. Our aim is to help users navigate their mental health journey and progressively move towards actual social interaction.

physIQ

Purdue University

[Update (8.2023): physIQ has raised a total of $27.09M in funding through 8 funding rounds]. physIQ has created wearable sensors for continuous, remote patient monitoring to provide predictive insights. The platform gives clinicians 24/7 access to provide treatment and care through virtual or hospital-at-home models, it helps to avoid hospital re-admissions by altering the team to life-threatening events in advance, and helps patients take charge of their own care to improve disease management.

Six-month mortality risk estimation from electronic medical record

University of Minnesota

Utilizes a lightweight algorithm and machine learning collected for 8 variables during the first 48 hours of hospitalization to predict the risk of 6-month mortality. Researchers at the University of Minnesota have developed a lightweight algorithm using machine learning for predicting the risk of 6-month mortality at the time of hospital admission. Using just 8 different variables collected during the first 48 hours of hospitalization, this algorithm predicted death within 6-months with an AUC of 0.92. The discriminative ability of this algorithm has been shown to be significantly better than historical estimates of clinician performance. This algorithm can be a critical tool in supporting clinical decision-making at admission and in evaluating suitable options such as transfer to tertiary referral center, serious illness care-conversations in high-risk patients, patient/family counseling, and palliative care utilization.

Nanowear

Comfortable cloth nanotechnology undergarment captures from a patient at home more than 85 medical biomarkers that can be monitored by medical staff remotely. (University of Arkansas)

Araqev

Purdue University

Araqev uses machine learning to create software solutions for closed-loop, smart control in additive manufacturing. Araqev’s patented machine learning algorithms enable users to design and print new shapes and processes with greater accuracy, resulting in less wasted scrap and machining time.

Genesis Therapeutics

The company boasts the world’s most advanced molecular AI platform that combines 3D structure-aware deep neural networks, new molecular simulation methods, and a massively scalable molecular generation engine.

Atomwise

The company’s proprietary AtomNet technology identifies new small molecules for therapeutic targeting of difficult proteins. Atomwise is a venture-backed drug discovery platform company powered by robust and evolving machine learning algorithms. The proprietary AtomNet technology identifies new small molecules for therapeutic targeting of difficult proteins. Atomwise has wholly-owned pre-clinical assets in immunology, co-developed assets in oncology, hematology, and immunology, as well as several stealth candidates in discovery phase. (University of Toronto)

Alto Neuroscience

Using AI-driven brain biomarkers to match patients with the right drug.

BiomeSense

University of Chicago

[Update (8.2023): The company raised $6 million through a combination of Seed 3, and Seed 4 funding on February 14, 2023] Integrating proprietary technologies, the GutLab, “smart bathroom” technology for continuous patient microbiome tracking & MetaBiome, a cloud-based bioinformatics platform. Novel tools to continuously track, analyze, and store individual microbiome profiles, providing vastly more data than, and at a fraction of the cost of, current practice. Creating the GutLab, a novel “smart bathroom” technology for continuous, at-home microbiome tracking & MetaBiome, a cloud-based bioinformatics platform. This platform is a generational leap over existing measurement tools: (1) much cheaper and more scalable, (2) produces & analyze dense time-series data, unlocking an entire dimension of never-before-accessible biomarkers, and (3) has far higher accuracy & precision, ensuring all data generated can be stored in a single, standardized database – a first for the microbiome field.

smartHER

smartHER is a mixed reality (MR/AR)-based medical device company focused on developing innovative solutions for gynecologic procedures, with an initial focus on rehauling how MRI scans are utilized for uterine fibroid removal. The company is spinning out of Weill Cornell Medicine (WCM) where it has gained significant traction by developing a MVP. It has received multiple awards for its novel product design, established strategic partners in several relevant domains (e.g., women med device, cloud computing, and MR software), and is in the process of validating the technology through a clinical study. smartHER is looking to hire its inaugural Chief Executive Officer (CEO).

zTouch Networks

The cellular industry has begun a transition toward open, programmable, and cloud-native architectures to reduce cost and address major management challenges. This transition (like the telecom migration to SDN) creates a significant new business opportunity for a flexible automated management system. zTouch Networks leverages years of research and development to provide the industry’s first data-driven, intelligent and autonomous network operating system to power this industry upgrade. The zTouch has extensive relationships with key industry partners and manages the world’s largest RF emulator, Colosseum (a $30M+ resource) and the testbeds in the NSF Platforms for Advanced Wireless Research (a $100M program). zTouch has an aggressive plan to pilot its platform in the next 18 months and is looking for partners and investors in this effort. It is looking to raise $5M to accelerate its pilot and add world-class leaders to run and grow the business.

WiLO Networks

WiLO Networks bridges the gap between passive RFIDs and high power Long Range (LoRa)/Sigfox to enable precision agriculture, military surveillance, fire mitigation, smart highways, and other IoT applications. Currently, WiLO Networks focus is to provide solutions for precision agriculture. WiLO Networks is building a novel physical layer communication technology based on low-power integrated circuits (ICs), which can be embedded in sensor nodes and gateways at very low cost. This physical layer technology combined with novel network architecture and protocols, as well as intelligent machine learning techniques promises a 10 year lifetime for sensor nodes powered on millimeter-scale batteries. These ultra-low power sensor networks are the key to precision agriculture, monitoring the health of buildings/bridges, and military surveillance. WiLO's solutions can reduce waste to promote sustainability and carbon neutrality.

cAPAcity Genomics

University of California, Irvine

Genome-wide association studies (GWAS) have identified thousands of noncoding variants associated with human traits and diseases. However, translating these variants into therapies continues to be a significant challenge. Alpaca Genomics has constructed a multi-tissue atlas of human 3′ UTR alternative polyadenylation (APA) quantitative trait loci (3′aQTLs), connecting thousands of noncoding GWAS variants with the APA of target genes, identified in 49 tissues isolated from 838 individuals (sourced from the Genotype-Tissue Expression Project). Alpaca Genomics is using 3’aQTLs to discover novel APA-linked susceptibility for many human diseases, such as diabetes, prostate cancer, coronary artery disease (CAD), Alzheimer’s Disease (AD), Parkinson's disease, and Amyotrophic lateral sclerosis (ALS).

Aromha

Harvard University

Smell loss is an early indicator of infectious and neurodegenerative disorders. In COVID-19, for example, objective smell loss may occur in >90% of patients. Though molecular (PCR) tests are effective in diagnosing SARS-CoV-2 infection, with moderate sensitivity and high specificity, they typically are costly (>$50), with long turnaround times (up to 5-7 days) and have not been as effective in controlling asymptomatic spread. The Aromha Smell Test complements molecular tests with high sensitivity and negative predictive value and can be scaled quickly to provide an important new tool to prevent community spread of COVID, with an at-home, non-invasive, safe, and cost-effective screening test that provides instantaneous results. This platform technology, developed based on 20 years of olfactory research at Harvard, can also be utilized to provide an early signal and improve care in critical neurodegenerative diseases such as Alzheimer's, Parkinson's Disease, and Traumatic Brain Injury.

Free Dynamics

Our silicon-based quantum sensor can continuously sense and record information without the need for batteries. By interrogating the stored information at a later time instant, the recipient can retroactively monitor the environmental conditions the sensor experienced. Advantages: Continuously logs data from environmental stimuli without external power or batteries / Provides cumulative, time-integrated information for later retrieval / Leverages mature silicon manufacturing to reduce cost / Reduces gap in coverage by augmenting existing periodic, battery-based solutions /

FloraPulse

The FloraPulse system is a microchip tensiometer (microtensiometer) that is embedded into the tree woody tissue and directly measures the water status, known as water potential. Because the measurement is taken directly inside the water-carrying tissue, readings are very accurate and reliable. You receive daily midday stem water potential readings, along with science-backed irrigation recommendations. Since 2017, we raised $1.2M in non-dilutive SBIR research awards to develop microT, and successfully field tested the product in almond, grape and prune commercial orchards and vineyards. In 2019-2020, we received $50k in customer deposits and sold the first 60 subscriptions ($90k) to 15 customers in the US, Chile and Australia. Customer feedback has been very positive. We are looking to hire a seasoned CEO to help the company raise funds, build partnerships, and continue increasing product sales in the US and abroad.

Pulmera

[Update (8.2023) SBIR/STTR funding total: $281k] Pulmera enables x-ray visualization of the tracheobronchial tree to aid physicians in guiding endoscopic tools in the pulmonary tract. Early diagnosis and treatment are vital for improving lung cancer survival rates, and tissue biopsy is necessary for diagnosis. However, performing a lung biopsy is difficult due to the complexity of the highly branched airways of the lung, making it difficult to access and obtain the tissue and the procedure can pose a risk to the patient. Electromagnetic navigation bronchoscopy (ENB) is the safest way to obtain a biopsy but diagnostic success is limited by poor real time visualization of significant portions of the lung. Should the biopsy procedure be unsuccessful, patients may then need to have the tissue surgically removed. In a high number of these cases, the nodules are found to be benign. Pulmera will greatly improve the ability to obtain a diagnosis for the patient using ENB.

Eterna

As part of a portfolio of COVID-19 inspired innovations aimed at advancing RNA vaccines and tools, Stanford researchers have developed a secured, invite-only version of their popular Eterna platform for designing mRNA vaccines, called Inceptive. Inceptive is an online application that integrates RNA folding algorithms, a video game interface, and associated computational methods to revolutionize vaccine design and RNA structure prediction. The new, secured version of the platform is able to host selected participants to work in a confidential manner on problems such as designing improved mRNA vaccines that can be translated to clinical trials by industry partners and other collaborators. The data and designs generated by Inceptive users may be used to develop improved mRNA vaccines immediately for the COVID-19 pandemic.

Bioada

Rutgers University

The scientific community is continuously trying to improve their understanding of genetic mechanisms in biological systems and finding biomarkers for diagnosis, prognosis and treatment. With growing accessibility, still, only the minority of investigators in the life and medical sciences has the means to analyze and leverage this enormous treasure of data. Bioada is an integrated, easy to use and interactive genomics data analysis platform for the broader community of life scientists.

M^3

We treat faces as if they were feet, and that’s absurd. Unlike feet, faces are 3D, yet we still measure them using 2D objects such as paper cutouts in the massive $6b market to fit people with masks. This doesn’t cut it, and the data backs it up: 50% of Americans don’t wear the CPAP masks they’ve been prescribed because of these fit, comfort, and convenience issues. The only reason we’ve tolerated this is that until recently there has been no better way to get good 3d measurements of your face without lots of specialized tools. We solve this problem by making it as easy as taking a selfie to get precise 3D measurements of your face.

Stork AI

Stork AI is leveraging its strong foundations in reproductive medicine, big data, and artificial intelligence to create next-generation fertility products that ultimately help people have babies. It is commercializing a decision assessment tool comprised of patent-pending, AI-based software (“STORK”) that reliably assesses embryo (blastocyst) quality. STORK was developed using a proprietary, multi-focal embryo image dataset from Weill Cornell’s Center for Reproductive Medicine. STORK can also predict genetic defects such as aneuploidy, which involves an abnormal number of chromosomes in the embryo.

UV-C N95 Sterilization

University of Chicago

Currently there are several solutions under consideration for disinfecting N95 respirators for re-use, with UV-C as the preferred solution because of ease of deployment and widespread applicability. Problematically, present UV-C disinfection solutions are limited by shadowing, which prevents exposure of the masks to the required effective dose of UV irradiation. The inventors utilized UV-C light field modeling and extensive test measurements to develop a proprietary arrangement of lamps for disinfecting. The configuration eliminates shadowing, allowing for full irradiation and disinfecting of the contaminated N95 respirator surface in the shortest amount of time.

Parallel Works

University of Chicago

[Update (8.2023): SBIR/STTR funding total - $572k] Parallel Works is a web-based platform that simplifies and automates the complex workflow of parallel computing. They speed up simulation and analytics campaigns across industries by making parallel computers from hybrid clouds and clusters easier to use. Their platform is built on the Parsl and Swift parallel scripting technologies developed over the last decade by Argonne National Laboratory, and is designed to run simulation and analytics on the world's largest computing resources. (Sept. 2021 -Argonne and Parallel Works won the Federal Laboratory Consortium’s (FLC) Midwest Regional Award for Excellence in Technology Transfer for bringing Argonne’s Machine Learning–Genetic Algorithm (ML-GA) design optimization software to commercialization.)

AlvaHealth

Yale University

[Update (8.2023): SBIR/STTR funding total - $1.48M, Venture funding total - $0.74M] Getting immediate medical attention is critical after a patient has experienced a stroke. However, stroke symptoms are often not identified by the patient or family members until it is too late to administer treatment. There is currently no wearable-linked mobile app which specifically detects a stroke incident. AlvaHealth is pairing wearable devices with machine learning to detect a stroke incident immediately based on the activity in both arms of the patient. Early detection of stroke can improve the outlook for patient recovery. (Update) Alva Health was part of MassMEDIC's IGNITE 2021 cohort and also participated in the MassMEDIC Startup Stadium during BIOMEDevice Boston 2021. Alva Health is the recipient of the $350,000 grand prize as the winner of its 2021 MedTech Global Competition.

Surgical ai

Harvard University

Operating rooms are often not efficient and are costly to hospitals. Solutions to increasing efficiency neglect to monitor errors in real time which can be stopped and improve efficiency from the time of the incident. This technology pairs artificial intelligence with real time monitoring of operating room procedures to increase efficiency of hospital operating rooms.

My Gene Counsel

Yale University

[Update (8.2023): Venture funding total - $3.38M] My Gene Counsel has created scalable, digital technology that pairs specific genetic test results with accurate, continuously updating information for clinicians and consumers. By helping patients and doctors become aware of the implications of genetic testing results, My Gene Counsel can help improve patients' lives and avoid unnecessary risky medical procedures.

Clarasim Systems

ClaraSim Systems, Inc. has developed a computer simulated environment in which surgeons can perform surgery on virtual bone using virtual instruments. By combining patient-specific data with a powerful simulation engine, we are able to create 3-D patient models that can be explored and modified in real-time with virtual surgical tools providing both haptic and visual feedback. Our system enhances the surgeon's ability to perform skilled surgery by enabling them to rehearse drilling through accurate representations of the patient's bony and fragile structures. The anatomical insight gained from interacting with the simulation provides guidance during actual surgery leading to better outcomes. While the system enables preoperative rehearsal, it is also used as a teaching tool, giving trainees the opportunity to experience many different cases in a safe and efficient setting. The technological and clinical capabilities of the product stem from over 30 person-years of research conducted by the company founders.

Powernet

Stanford researchers have developed an architecture and control scheme for the coordination of distributed energy resources (DER), such as solar and storage, to minimize operation cost, enhance network reliability, and provide DER aggregation. The availability of electric load and generation data in electric grids varies both spatially and temporally due to: the random nature of loads and renewable generation; distributed locations of the loads and DER; and communication delays. Stanford researchers have found that control schemes that utilize local information (within the firmware of the storage unit, or in a home automation appliance) and delayed information to a global controller (e.g., collected from smart meter readings) perform near the ideal, but unimplementable, theoretical limit of performance.

Tharzen

University of Chicago

Relying on developers to do web app maintenance is expensive and time-consuming. Many content management system (CMS) operators like Wordpress claim you can 'do it yourself' visually, but after 20-50 plugins, visual interfaces fall short as many dependencies fail. Tharzen offers a visual editing interface for any live website under any CMS, even hard-coded and dynamic web apps.

3rd Arm Inc

Articulated Wearables to enhance human productivity. 3rd Arm is prototyping a wearable, articulated robotic device that can be attached to a person at the hip or other location to augment human task productivity. This mechanical "third arm" has many uses such as assisting abled users (e.g. holding additional tools to enhance work), helping disabled users (e.g. providing support and lifting objects), and as a haptic interface for interaction with robotics systems and AR/VR experiences. 3rd Arm is incorporating the latest robotic technology with a newly designed 4-state brake mechanism in joints for advanced operations.

MyophonX

Solutions for silent speech production lack innovation, cultural acceptability, and often involve invasive surgery. MyophonX is cutting-edge wearable technology for silent communication, with applications to stroke and laryngectomy patients as well as voice searching.

Singularity

Harvard University

Singularity Energy, a cutting-edge grid decarbonization platform, developed by experts from Harvard, MIT, and Johns Hopkins, successfully closed a $4.5 million Seed Round with contributions from Spero Ventures and Energy Impact Partners, among others on January 27, 2022. Their platform, backed by real-time carbon dioxide signals, optimizes energy resources through carbon forecasting and optimization algorithms, enabling companies to balance emissions management and economic benefits. They recently welcomed Tesla co-founder and Spero Ventures partner Marc Tarpening to their board of directors. Singularity Energy has forged alliances with the New York Power Authority & EPRI and also obtained a $1.2 million NSF Grant in May 2022.

Synaural

Northwestern University

The Synaural platform uses engineered acoustic probes to elicit specific neural activity within the brain. A robust, easy to use, non-invasive headset records the neural activity and patented algorithms extract unique metrics that provide objective insight to the subject’s neural health and can be used to guide treatment in a meaningful, measured way. To date, the metrics have demonstrated enough specificity to be correlated with various conditions e.g. concussion, learning disabilities (e.g. Autism, reading, dyslexia), and hearing.

bioProtonics

University of California, Santa Barbara

[Update (8.2023): SBIR/STTR funding total - $150k, Venture funding total - $2.86M] Many diseases can only be diagnosed properly by looking at sections of the tissue post-mortem or from invasive biopsies. Imaging of subtle textural aspects of tissue is not possible due to low resolution in magnetic resonance (MR) images. bioProtonics has developed a method to measure tissue texture using MR data without the need for rendered images. In many diagnostic workflows, the bioProtonics technique could replace biopsies. Such applications include neurodegenerative disease, liver disease, osteoporosis, cancer, lung disease, prostate disease. (Update 2019 - 2021: $1,049,785 + $782K Seed Funding)

Vine Robot Technologies

University of California, Santa Barbara

Soft robotics shows promise for creating robots which are better able to navigate narrow and variable environments. The vine robot is able to extend its length many thousands of percent its body length with an internal pressurized vessel, which can be manipulated to change the direction of the robot tip. In testing, the vine robot is able to navigate through small passages and can even autonomously navigate towards light source with the addition of a camera.

OptoVibronex

Rutgers University

The current standard for distinguishing between benign and cancerous skin legions require an invasive skin biopsy followed by a waiting period for lab results for diagnosis. OptoVibronix is eliminating the need for invasive skin biopses to diagnose a skin legion as cancerous or benign. The technology scans the skin legion and results in a diagnosis in just 15 minutes. By avoiding skin biospy, it improves the patient experience and efficiency of diagnosis and reduces healthcare costs.

Tendo Technologies

Princeton University

(Update: Raised an estimated $2 million from Rhapsody Venture Partners and Tyche Partners in 2023). Founded in 2017, Tendo Technologies is an innovative firm emerging from the Marcus Hultmark research lab at Princeton. The company specializes in advanced flow sensing/measurement technology. The scalable technology uses nanoscale conductive ribbons to achieve extreme sensitivity for gases and liquids. Tendo's tech, packaged with tailored components for specific applications, proves useful across numerous industries, including medical, agricultural, HVAC, and manufacturing sectors.