Due to the rapidly growing use of opioids and its analogs (and the increase of fatal drug overdoses), Narcan is rapidly becoming the new Kleenex. Vaccines offer a promising treatment alternative to counteract opioid use disorders (OUD) and fatal overdoses. Vaccines generate opioid-specific antibodies that bind the target opioid, reducing the drug's impact on the brain and preventing the drug-induced effects. Futura is developing vaccines, antibody-based strategies, and small molecules to counteract opioid use disorders and overdose. These approaches can improve the lives of people living with substance use disorders or who are at risk of fatal overdoses. The team is testing the first in-human vaccine against the euphoric and toxic effects of oxycodone and have initiated Phase I Clinical Trials. Futura and UMN is seeking a leader co-found the venture with Dr. Pravetoni.
The heart is a muscle, and like all types of muscles, it can be injured. In humans, heart muscle is not able to regenerate after injury. This can lead to heart disease which develops over time, eventually leading to an untimely death. Prolifagen is combining discoveries in gene therapy, materials science, and drug delivery to bring human tissue regeneration therapies to reality. The lead drug candidate is a proprietary microRNA embedded in a hydrogel construct to enable a single-shot therapy for heart tissue regeneration, bypassing the need for exogenous stem cells. Prolifagen is seeking seed funding for IND-enabling porcine studies and a new CEO to lead the team into their next chapter.
The cellular industry has begun a transition toward open, programmable, and cloud-native architectures to reduce cost and address major management challenges. This transition (like the telecom migration to SDN) creates a significant new business opportunity for a flexible automated management system. zTouch Networks leverages years of research and development to provide the industry’s first data-driven, intelligent and autonomous network operating system to power this industry upgrade. The zTouch has extensive relationships with key industry partners and manages the world’s largest RF emulator, Colosseum (a $30M+ resource) and the testbeds in the NSF Platforms for Advanced Wireless Research (a $100M program). zTouch has an aggressive plan to pilot its platform in the next 18 months and is looking for partners and investors in this effort. It is looking to raise $5M to accelerate its pilot and add world-class leaders to run and grow the business.
Mitral regurgitation (MR) is the most common heart valve disorder in the US, with over 4 million individuals affected globally and an incidence of over 250,000 annually. Results of severe MR frequently lead to shortness of breath and fatigue and to potential heart failure and death without treatment. Open heart surgical Mitral valve repair (OHMVR), is the gold-standard option to restore the valve function and patient prognosis. Today minimally-invasive options (transcatheter therapy, TMVR) allow surgeons and interventional cardiologists to perform valvular repairs without opening a patient's chest and represent a safe alternative in a subset of frail patients. The MitralPrint device will be the first endovascular, piezoresistive pressure sensor designed to quantify myocardial contraction fraction (MCF) in real-time during both OHMVR and TMVR allowing the surgeon to record an objective parameter on the MR. This eliminates the need for subjective trans-thoracic ultrasound assessment.
Lubrication is critical in biology for tasks such as joint flexing and eye movement, but aging and disease can reduce natural lubrication. Current lubrication solutions either exhibit a short half-life (such as cortisone and hyaluronic acid) or poor long-term bio-compatibility (such as exogenous lubricants like glycerin-mineral oil), leaving a market opportunity to develop a durable, bio-compatible lubricant. synLubricin is a stable, and scalable, long-term bio-lubricant for joints, eyes, and medical devices. synLubricin has been developed in FDA-approved human cell culture systems and is able both to resist cellular adhesion and lubricate biological surfaces, such as cartilage. synLubricin is searching for a co-founder to help develop this venture opportunity.
Periodontitis is a chronic destructive inflammatory disease affecting up to 50% of Americans for which there are limited treatment options. The US market alone will be $900M for dental implants by 2024. Current treatment options for periodontitis include guided tissue regeneration, with non-absorbable, difficult to manipulate products. DontoFilm has developed a smart periodontal membrane with chemotactic coating which facilitates bone regrowth while staying flexible and resorbable.
Cell replacement therapies hold tremendous promise for type 1 diabetes, hemophilia, lysosomal storage diseases and other cellular disorders. EncapBio Systems has developed technologies for safe and functional delivery of cell therapies ready for pre-clinical development. Most of our recent work, ranging from material synthesis and device fabrication to cell engineering and process integration, has been centered around the goal of successfully delivering safely insulin producing cells with long-term function for T1D patients. EncapBio Systems builds upon 10 years of research of high quality proof-of-concept publications and patent applications. EncapBio Systems is seeking co-founders and investors to help build the next biomaterial platform for cell therapy.
Valerian Materials is leading the way in renewable, degradable, and recyclable polymers. The biomass derived materials have applications as resilient foams and elastomers as well as tough plastics and thermosets. The principal technology relies on efficient and economical fermentation of sugar to give small molecules that can be catalytically converted to polymers in high yields at low temperatures with controlled molar mass. The versatility of the polymer platform is a key aspect and allows for broad penetration in a wide variety of industries. Valerian Materials is seeking a business executive to join the company and lead the development and execution of the next stage of the business growth.
Drug discovery remains an expensive and time-consuming process. Promising compounds proceed through clinical trials only to have many failures before FDA approval. Aracari’s vascularized microphysiological systems are leading the way in preclinical drug testing. Aracari’s vascularized 3D Vascularized Micro-Organ (VMO) and Micro-Tumor (VMT) models incorporate perfused human vasculature for the physiologic delivery of nutrients, drugs and immune cells to multiple tissue and tumor types. These powerful next-generation tools are accelerating development of immuno-oncological and other therapeutics for more optimal patient outcomes. Aracari is seeking a Chief Business Development Officer as they expand their C-level team.
Datacenters are a critical component of the modern internet, responsible for processing and storing tremendous amounts of data in the “cloud.” Datacenters also provide the computational power needed for handling “big data,” a growing segment of the U.S. economy. Xscape is making the next-generation photonic communication networks for high-performance computation. Such networks are crucial for data centers, machine learning, and artificial intelligence. Our technology is based on our world-leading photonic-chip technology combined with massive frequency-division multiplexing, which allows for ultrahigh bandwidth communications up to 25 times faster than products currently on the market. This scalable technology is smaller and less expensive than current products and requires less power. The scientific founders are seeking a dedicated CEO to build the company.
Mammalian cell tissue culture is critical to biomedical research and to the production of many blockbuster drugs. Animal-sourced sera provide the growth factors and cytokines that are essential for tissue culture. After an initial $1.5 million investment, TildenBio's photosynthetic platform is suited to producing biomedical proteins economically, simply, and at large scale. We have achieved expression levels of over 20% of total protein. TildenBio’s technology is simultaneously applicable to a number of markets, including the diagnostic market, edible vaccine market, industrial enzyme market, and possibly next-generation antibiotic markets. With an initial beachhead focused on producing low-cost growth factors and cytokines as replacements for animal-sourced tissue culture sera, TildenBio is searching for a CEO to lead the team into its next chapter.
Broad-spectrum antiviral therapies do not exist, tragically hindering our ability to respond to viral outbreaks and pandemics. We need new approaches to treat these diseases, as existing therapeutics are very narrow-spectrum and take many years to develop. Carver Biosciences is a startup company developing CRISPR-based therapies for RNA viruses that infect humans. Carver’s approach is a programmable, platform technology that could offer a generalizable solution for treating many viruses, as targeting is dictated by a guide RNA sequence. The underlying technology, CARVER, was developed by founder Cameron Myhrvold during his time as a postdoc at the Broad Institute of MIT and Harvard and was published in Molecular Cell in 2019. Carver recently closed a seed round and is looking to expand it's team.
WiLO Networks bridges the gap between passive RFIDs and high power Long Range (LoRa)/Sigfox to enable precision agriculture, military surveillance, fire mitigation, smart highways, and other IoT applications. Currently, WiLO Networks focus is to provide solutions for precision agriculture. WiLO Networks is building a novel physical layer communication technology based on low-power integrated circuits (ICs), which can be embedded in sensor nodes and gateways at very low cost. This physical layer technology combined with novel network architecture and protocols, as well as intelligent machine learning techniques promises a 10 year lifetime for sensor nodes powered on millimeter-scale batteries. These ultra-low power sensor networks are the key to precision agriculture, monitoring the health of buildings/bridges, and military surveillance. WiLO's solutions can reduce waste to promote sustainability and carbon neutrality.
Genome-wide association studies (GWAS) have identified thousands of noncoding variants associated with human traits and diseases. However, translating these variants into therapies continues to be a significant challenge. Alpaca Genomics has constructed a multi-tissue atlas of human 3′ UTR alternative polyadenylation (APA) quantitative trait loci (3′aQTLs), connecting thousands of noncoding GWAS variants with the APA of target genes, identified in 49 tissues isolated from 838 individuals (sourced from the Genotype-Tissue Expression Project). Alpaca Genomics is using 3’aQTLs to discover novel APA-linked susceptibility for many human diseases, such as diabetes, prostate cancer, coronary artery disease (CAD), Alzheimer’s Disease (AD), Parkinson's disease, and Amyotrophic lateral sclerosis (ALS).
Velox Biosystems plans to develop and launch a rapid diagnostic product for urinary tract infections (UTI), a problem that affects nearly 50 percent of the population at least once in their lifetime. This decision follows the startup’s completion of a recent clinical feasibility test that yielded impactful clinical data for the company to move forward with the next steps in development. Velox Biosystems has created an ultra sensitive rapid detection system that provides for no or minimal sample processing, high throughput scanning of large sample volumes, with single target sensitivity and unprecedented speeds. Utilizing a digital droplet molecular detection platform, we are developing a point of care diagnostic device to address critical unmet needs in the UTI, liquid biopsy, and sepsis spaces. Total available market of over $1 Billion.
AgingSense is a company focused on developing technological solutions to complex problems of aging to improve quality of life of older adults. The first technological solution being developed is Heart Failure Monitoring Socks. This wearable sock technology monitors persons with heart failure for exacerbations as well as response to treatment. The socks monitor for changes related to heart failure specifically, leg edema, using stretch sensors, and fatigue using actigraphy and gyroscopes. Data is sent by blue tooth to an app which is run through an algorithm in a secure cloud that triggers a message to the individual with HF, a trusted other and/or their provider of changes in their condition. The ultimate goal is to improve heart failure management to keep persons with heart failure home and out of the hospital with a better quality of life.
Tandem Repeat Technologies, Inc. (TR Tech) is the market leader in Sustainable Textiles Manufacturing. TR Tech has created the world’s first programable textile which is 100% sustainable, self-healing, and fully biodegradable. Established in 2018, TR Tech has developed revolutionary technology that combines materials science and biomanufacturing to produce performance composites with tunable properties. The technology is covered under five (5) issued US patents and additional five (5) pending with Squitex. The physical characteristics of Squitex will allow it to be adopted into many products and technologies. It is a platform performance material that is renewable, green, strong, flexible, self-healing, energy efficient and friendly to most of today’s manufacturing processes. The use will only be limited by the creativity of application and the ability to produce the quantity of material to meet market demand.
Sense4me is developing a digital platform that predicts relapse in patients with alcohol use disorder. Through wearable sensors, sense4me provides real-time measurements of a patient’s sympathetic nervous system and hypothalamus, data that can act as an alert to subdue cravings before they cause the patient to relapse. This just-in-time intervention powered by personalized health analytics has the potential to reduce relapse rates, which can be as high as 80-95% among patients in their first year of treatment for alcohol and nicotine addiction. Dysregulation of the stress system has been associated with a shorter time to future relapse in alcoholics. By monitoring stress responses, this technology empowers the 14.8M Americans with alcohol use disorder to actively participate in their treatment and take control of their cravings. A collaboration between Columbia’s Dr. Lili Deligianni and Dr. Nasir Naqvi, sense4me is seeking $500K in seed funding to complete a wearable prototype and accompanying software.
Lithium-ion (Li-ion) batteries are used in many products such as electronics, toys, wireless headphones, handheld power tools, small and large appliances, electric vehicles, and electrical energy storage systems. If not properly managed at the end of their useful life, they can cause harm to human health or the environment. Princeton NuEnergy is revolutionizing the material supply chain with its patented low-cost process for producing high quality cathode active materials from spent lithium ion batteries. With successful operation of our lab scale plant and strong relationships throughout the electric vehicle supply chain we are building out our team to execute our production scale manufacturing plants starting in 2021.
GenoTwin is a next-generation genomics platform that combines leading genomics expertise with data science to transform the detection of pathogens and our understanding of individual immune responses to them. We envision a future where data-rich pathogen and immuno-surveillance are a part of the public health fabric, ushering in an era of precision medicine and enlightened policy-making. Specifically, we have developed an innovative genomics platform that combines cutting-edge capabilities in genomics, artificial intelligence, and bioinformatics to support clinicians, public health officials, and researchers. Out solutions encompass four key areas: ) Pathogen detection, 2) Pathogen surveillance, 3) Immune/resistance assessment, and 4) Precision treatment development. We were founded by leaders in this field and are supported by a Scientific Advisory Board of widely esteemed scientists and practitioners in genomics, virology, infectious disease, and epidemiology.
The HoloAnatomy® Suite is the first product built on CWRU’s Mixed Reality Education Platform (MREP), and is the culmination of over seven years of artistic and programming development launched through a partnership with Microsoft. Case Western Reserve University was Microsoft’s inaugural Medical Education Lead collaborator, gaining access to the first generation of the HoloLens prior to public launch. Developed to be the primary Anatomy course used in CWRU’s School of Medicine, it is now used at several premier schools of medicine across the United States, UK, and European Union. HoloAnatomy has an executive sales team in place with $600k in signed contracts to date, currently growing at 80% annually. HoloAnatomy is seeking a CEO responsible for building out a NewCo team to commercialize the Mixed Reality Education Platform (inclusive of the HoloAnatomy Software Suite), lead fundraising as needed, furthering the development of the product, and commercializing the technology.
KneeMo addresses problems associated with musculoskeletal disorders including sports related injuries and chronic disease such as osteoarthritis (OA). The potential market is substantial since musculoskeletal disorders affect more than one out of every two persons in the United States over age 18 and three out of four over age 65. Osteoarthritis alone accounts for 242 million people in the world who live with activity limiting symptoms. Pharmaceuticals, often used to alleviate the musculoskeletal pain come with side effects that can include addiction. KneeMo takes a novel mechanical approach to engage multimodal sensory pathways that signal pain using cutaneous mechanical stimuli (e.g., vibration) where over stimulation in one mode of the system (e.g., vibration) can gate response in other modalities (e.g. pain). KneeMo was shown in a placebo controlled clinical trial to provide an effective and safe alternative to pharmacological interventions to reduce pain and enhance function.
Dermal fillers are implantable medical devices injected into the skin to help fill in facial wrinkles, restoring a smoother appearance. In 2018, there were >2,600,000 dermal filling procedures performed in the US, and the market was estimated to reach $10 billion by 2023. Despite the high demand, no dermal filler has been approved by FDA for injection in the superior portion of the face. High blood vessel density around the eye presents the risk for vascular occlusion leading to skin necrosis or blindness. UCLA researchers led by Prof. Timothy Deming and Michael Delong reported a novel dermal filler material, polyion-complex deblock copolypeptide hydrogels (PIC-DCH), which is safer than the currently used hyaluronic acid.
The field of brain-machine interfaces has advanced significantly over the past two decades, especially in its successful transition into human clinical trials. However, this progress has relied largely on wired, invasive sensors for the acquisition of neural data with high spatial and temporal resolution. Neurograins represents the first completely wireless network of sensors in neural application, consists of ensembles of implantable, sub-millimeter, individually addressable microchips.
Foodborne illness is a significant health and economic problem globally. Cross-contamination of food by pathogens via surfaces of food processing equipment is a leading risk factor in foodborne disease outbreaks. Antimicrobial coatings that make food contact surfaces self-sanitizing have potential to reduce cross-contamination and represent a $2.3B market opportunity. Despite that promise, the antimicrobial coating technology available for food contact surface applications is severely limited by a lack of food-grade coatings, lack of efficacy in high volume/organic matter environments, difficult application, high cost and challenges in use with legacy equipment. We have developed novel antimicrobial coatings to make food contact surfaces self-sanitizing to prevent cross-contamination. The coatings are made of food-grade, FDA GRAS materials. They are safe, effective, low-cost, environmentally friendly and useable on legacy equipment. The underlying technology was developed at University of California-Davis.
Monoclonal antibodies (mAbs) are a $300B market, about $20B in diagnostics and $30B in antiviral therapeutics. Yet antibodies require poorly scaling, expensive mammalian cells, vary with batch, are environmentally unstable, and are subject to escape by viral strain evolution. Protein Architects is developing beta solenoid proteins as “molecular Legos” for applications in self-assembly of nanoparticle based devices and materials. Our polyvalent, environmentally robust viral decoy proteins for antigen diagnostics and therapeutics can be scalably produced in microbial GMP facilities at 1/50 the cost per binder yet bind up to 1000000x stronger than antibodies. As receptor decoys, they align with viral evolution, and modular human design makes immunocompatible therapeutics. We are seeking seed financing and regulatory advising on our in development viral decoy antibody substitutes for SARS-CoV-2 antigen diagnostics and therapeutics. We are positioned to make a difference in this pandemic, and future viral threats.
The continuous emergence and rapid spread of antibiotic resistant bacteria and antimicrobial resistant Candida has caused serious environmental and public health issues worldwide due to increasing difficulty in treating infections. Triggered drug delivery systems that limit exposure to antibacterials and/or antimicrobials can alleviate these challenges and help prevent resistance. We have developed responsive hydrogel systems to combat skin wound bacterial and fungal infections. ResponseGels is developing hydrogels that incorporate a degradable peptide sequence in the backbone that responds specifically to either 𝛽‐lactamases (βLs), the most common cause of resistance to antibiotics, or aspartic proteases (Saps) secreted by virulent Candida.
Neuromodulation is a rapidly expanding field of clinical neuroscience. Yet the widespread use of neuronal probes for recording and functional stimulation has been slow to develop, in part because of incompatibility problems with existing metallic and ceramic probes, as well as surgical complexity and potential tissue damage or infection during probe insertion. SME-Tronic is developing an electrode array made of shape-memory alloys and/or shape-memory polymers that can be inserted in a minimally invasive fashion through a needle or a small window in the spine or skull. Once inserted, the temperature-driven shape-memory response transforms the electrode shape into a shape that covers a more desirable area of the brain or spinal cord.
Neuralert offers non-invasive, wearable wristband devices which monitor asymmetric arm movement/weakness, a tell-tale sign of stroke. Neuralert’s proprietary algorithm accurately identifies stroke symptoms and immediately alerts medical staff to assess the patient and begin treatment. Neuralert’s technology can detect stroke in under an hour, which is more than 4 times faster than manual assessment processes currently used. The Center for Devices and Radiological Health (CDRH) of the Food and Drug Administration (FDA) has most recently granted Neuralert designation as a Breakthrough Device. Neuralert is searching for an advisory board member as they complete their seed round of fundraising.
Current point of care diagnostics frequently require blood draws (e.g., blood glucose monitoring for diabetes), hampering our ability to continuously monitor biomarkers such as cortisol and electrolyte levels. Understanding these levels are critical for a range of populations (high-performance athletes, military personnel, the chronically ill). Today, these biomarker analytes can be isolated from sweat with a new platform from FESSwise. The FESSwise platform is capable of broad biomarker monitoring and is pursuing cortisol detection as a first indication. The Freestanding Electrochemical Sensing System (FESS) platform features sweat sampling, electrochemical sensing, and data display / transmission, all within a self-contained wearable platform. The FESS-enabled smartwatch can be used to monitor the metabolite profiles of individuals in sedentary and high-intensity exercise settings.
While deep learning methods exist to guide protein optimization, examples of novel proteins generated with these techniques require a priori mutational data. Aperiam is taking the guesswork out of biotechnology with computer vision that illuminates critical parts of protein chemistry. We have trained a portfolio of computer vision algorithms on protein chemistry and use those algorithms to mutate genes for improved catalysis, expression, stability, and solubility. We are now using this approach to build our own suite of stabilized and solubilized enzyme therapeutics for direct delivery to the lung via nebulization and in parallel tailoring the computer vision framework to antibodies for expedited development and improved manufacturability.
SOLUtion Medical is an early-stage life science company developing user-friendly delivery systems for reconstitutable drugs. These devices improve patient outcomes through increased adherence to patient injected life-saving medication. We specifically aim to improve the administration efficacy of life-saving injectable medication with our TwistJect auto-injector for people living with adrenal insufficiency including Addison’s Disease and Congenital Adrenal Hyperplasia.
LignaMed is a biotechnology company developing breakthrough treatments for asthma, organ transplant viability, and pulmonary fibrosis. Many of these conditions suffer from localized ischemia-reperfusion injury due to local hypoxia. LignaMed's lead candidate LGM2605 is a novel small molecule synthetic lignan with anti-inflammatory and antioxidant properties. LignaMed expects to file an Investigational New Drug application with the U.S. Food and Drug Administration (FDA) in 2021 for Airway Hyperreactivity (AHR) in Th2-low asthma, a subtype of glucocorticoid resistant asthma. LignaMed is recruiting a CEO to take its breakthrough pharmaceutical and device technologies from pre-clinical studies to clinical trials and FDA approval and/or exit with a strategic pharmaceutical or device company.
KIN-Therapeutics is developing an AI-based computational platform integrating structural bioinformatics and machine learning with experimental approaches to identify small molecules targeting specific protein kinase targets and conformations. The Kinase Inhibitor (KIN) artificial intelligence (AI) is able to generate de novo kinase drugs with optimal selectivity. This technology will allow for better design and discovery of clinically relevant kinase inhibitors, which will have significant implications for cancer, Alzheimer’s disease, and even diabetes treatments. KIN focuses on a manageable and clinically-relevant chemical space and is entering into a partnership with a biotech company to design conformation specific immune-oncology inhibitors. KIN is looking for a CEO / Chair of the Board to lead the next steps for the venture.
There are over 900k cocaine addicts in the USA alone while worldwide cocaine usage rates have been growing at over 2% a year over the last decade. In the USA this results in over 15k deaths, 505k ER visits and $21B lost annually. Despite all of this, there is currently no FDA approved treatment for cocaine abuse disorder. AddGraft Therapeutics aims to be the first FDA approved treatment for cocaine abuse disorder utilizing our revolutionary gene delivery platform. Our treatment promises to be long lasting, minimally invasive and highly effective at treating the challenging aspects of addiction. AddGraft's technology is a novel skin-based gene delivery platform for treating cocaine abuse. Patients receive an autologous skin graft of genetically modified skin-stem cells which produces a dual molecule solution to effectively break down cocaine, preventing lethal overdose, and to behaviorally prevent frequent use, relapse, and developing of new addictive behaviors.
Between 2007 and 2017, there has been a 377% increase in the treatment of diagnosed anaphylactic reactions to food. The current standard of care is not enough to stem the tide of patients suffering the healthcare costs of food allergies. Phlaxis is an innovative immune tolerance company focused on providing a new approach to treating food allergies. Phalxis' allergen tolerance platform features proteins, or antigens, that are engineered to deliver precise, targeted allergy therapy, without the side effects of broad immunosuppression. Phalxis’ allergen-specific platform can be translated to virtually any food allergy, including the Big 8 of milk, eggs, peanuts, tree nuts, fish, crustacean shellfish, wheat, and soy.
Detecting and quantifying very low concentrations of disease biomarkers is important for the diagnosis and management of many disease conditions in their early phases. Technologies to detect low concentrations of biomarkers are only available in the advanced research or central clinical laboratories, due to high technology complexity and costs causing significant delay in reaching correct diagnosis. Instanosis testing platform enables ultrasensitive, low-cost and rapid quantitation of disease biomarkers. This platform has many applications in multiple instances, where rapid, convenient and ultra-sensitive biomarker detection is crucial for disease detection and treatment. The lead application is the ultrasensitive detection of SARS-CoV-2 antigen in the community setting using smartphones. Current diagnostic gold standard for SARSCoV- 2 is rRT-PCR, which requires expensive extraction instrument, thermocycler, facilities and trained operators to conduct and hours or days to turn around results.
Smell loss is an early indicator of infectious and neurodegenerative disorders. In COVID-19, for example, objective smell loss may occur in >90% of patients. Though molecular (PCR) tests are effective in diagnosing SARS-CoV-2 infection, with moderate sensitivity and high specificity, they typically are costly (>$50), with long turnaround times (up to 5-7 days) and have not been as effective in controlling asymptomatic spread. The Aromha Smell Test complements molecular tests with high sensitivity and negative predictive value and can be scaled quickly to provide an important new tool to prevent community spread of COVID, with an at-home, non-invasive, safe, and cost-effective screening test that provides instantaneous results. This platform technology, developed based on 20 years of olfactory research at Harvard, can also be utilized to provide an early signal and improve care in critical neurodegenerative diseases such as Alzheimer's, Parkinson's Disease, and Traumatic Brain Injury.
IMIJ Technologies is a startup from the labs of Columbia’s Dr. Scott Small and Dr. Frank Provenzano that focuses on novel approaches to broad neurological and psychiatric screening and diagnostics that can be applied to existing and conventional neuroimaging - structural MRI. IMIJ has successfully developed and adapted technologies initially researched at Columbia to a variety of existing conventional neuroimaging to develop statistically rigorous candidate biomarkers, as well a fully interpretable report detailing the results. IMIJ uses the same images frequently obtained to diagnose brain diseases, images acquired tens of millions of times a year in the US alone. IMIJ's proprietary software requires no additional data or MRI equipment. IMIJ has raised $1.1M seed funding to date and is seeking $9M with the goal of securing approval for indication in order to refine the development and pilot with a major hospital system.
PrevPanc is developing an improved prophylactic against pancreatitis caused by endoscopic retrograde cholangiopancreatography (ERCP), by targeting two key inflammatory pathways. Post-ERCP pancreatitis can be life-threatening, excruciatingly painful, and costly. PrevPanc is developing a more effective and practical treatment to prevent pancreatitis, with significant improvements beyond current options of indomethacin, stenting, and IV hydration. PrevPanc's therapy is a combination of a calcineurin inhibitor combined with indomethacin to target two distinct inflammatory pathways, achieving higher effectiveness than the current standard of care with minimal change in post-procedure care.
SmartScan2 is revolutionizing secure identification applications with unclonable polymer film-based, scalable technology. Most, if not all security devices in use today can be corrupted, counterfeited, or easily interpreted. Examples of these devices include personal identification cards, passports, pharmaceutical product tracking, currency, and product identification tags. One good example of this corruption involves credit cards. The fifty year old “magnetic strip” technology on a credit card has been corrupted by the use of illegal credit card “skimmers” attached to the credit card readers, and reported in the local news as prevalent on gas pumps and ATMs. The newer “chip” technology on credit cards can also be corrupted by the use of credit card skimmers which are becoming more prevalent in similar locations. SmartScan2's ID security is “unclonable” since it is vastly more difficult to corrupt, counterfeit or interpret the relevant information.
For low-resource internet-of-things (IoTs) like wearables, health-monitors, tags and sensors, existing authentication techniques (e.g., encryption, strong hash functions, pseudorandom number generators) might be impractical for securing access to critical data. This is because these devices have limited computational bandwidth; limited energy; and require real-time authentication. Static identifiers like bar-codes, product IDs, embedded physical unclonable functions (PUFs) or stored private keys are vulnerable to theft, counterfeiting, replay attacks or tampering. In this gap, Secure Dynamics is delivering enterprise-grade security solutions for energy-constrained Internet-of-things using zero-power timers. This solution uses zero-power timers to generate dynamic tokens that are secure against any power side-channel attacks, eaves-dropping and tampering. The hardware-software solution also supports mutual authentication, where the IoT device could also query and verify the trust of its reader.
Transfoam harnesses engineered microorganisms and renewable feedstocks to tackle plastic pollution at the beginning and end of the product lifecycle. Our proprietary bioprocess reduces the operating cost and environmental footprint of PHB manufacturing to overcome limitations currently hindering the industry’s growth. Plastic is at the forefront of our transition to a circular economy. We treat plastic waste as a valuable resource rather than a burden. By using a waste-based feedstock, we can both remove plastic pollution from the environment and provide a safe, accessible alternative. Polyhydroxybutrayte (PHB) is a bio-based polymer with similar properties as many traditional single-use plastics, except it degrades fully in the environment. PHB is both produced and consumed by microorganisms, leaving behind only traces of water and CO2 after use/disposal.
VitalCore is a Medical Devices Integration (MDI) solution that provides an integrated platform for showing the status, error messages, and patient info stored across all devices in various hospitals. VitalCore provides a visualized form of status data for easier comprehension and viewership by using tables, bar graphs, line charts, pie charts, and donut charts that enable the users to grasp the trend of the data and generate insights efficiently to improve patient care and reduce costs. Compared to similar device connectivity monitoring providers, VitalCore is focused on medical devices and has an active pilot that provides both an HL7 viewer and mobile application for healthcare professionals on the go. VitalCore is looking to expand their leadership team as they prepare to fundraise.
Functional brain imaging is an important tool to assess brain health in conditions like stroke, cognitive function, visual function disorders, Parkinson’s, and ischemia. However, the MRI scanners are too bulky and expensive to bring the assessment where it is needed at the bedside or in ambulatory settings. EsperDyne's Wearable Optical Brain Imaging (WOBI) system addresses the cost and portability gap, bringing affordable functional brain imaging to the bedside and beyond. The market size for fNIRS Brain Imaging Systems is currently estimated at more than $135M with a CAGR of 10% as the systems gain additional research and clinical importance. The two known competing research systems lack the voxel density and portability of the WOBI system. The WOBI technology is protected by two issued and two pending US patents and has 3 prototype generations.
Pepper Bio has developed the world’s first transomic drug discovery platform. We integrate phosphoproteomics, proteomics, transcriptomics, and genomics. This whole-stack solution to common drug discovery challenges reveals actionable insights that others miss to questions ranging from target ID to patient stratification using a global, dynamic, and causal approach. We’ve developed a full-stack drug discovery platform (PROSPER) to tackle complex, untreatable diseases.
Viral infections causing hepatitis are major contributors to human morbidity and mortality. Currently, there are no approved directly acting antivirals that cure two of these viruses - hepatitis B (HBV) and E viruses (HEV) – that account for close to 300 million infections world-wide. Our goal is to develop novel small molecule therapeutics that can be readily deployed to combat efficiently these diseases. To achieve this, we capitalize on discoveries and technical advances from our lab that put us in a unique position for targeted high through-put screens. We have already identified a lead molecule that is effective against multiple HEV genotypes, and we have uncovered a minimal set of host factors that are essential for HBV persistence.
Antimicrobial resistance is emerging as a growing global threat. Currently, more than 10 million people per year become infected by drug-resistant bacteria and those numbers are predicted to grow exponentially in the coming years. There is thus a pressing need for new antibiotics, and in particular for antibiotics with novel mechanisms of action. To address this need we have developed a novel pipeline for rapidly determining the mechanism of action of candidate antibiotics. With this approach we can fundamentally change the traditional antibiotic discovery pipeline by focusing our efforts on compounds with novel mechanisms of action (instead of the traditional efforts that prioritize based on chemical features and efficacy, leading to the rediscovery of similar compounds time and time again).
Volatile organic compounds (VOCs) are carbon containing molecules that have low boiling points and high vapor pressures causing them to evaporate into gas phase at ambient conditions. A wide range of VOC analysis devices are used in various industries for occupational exposure monitoring, environmental monitoring, process control, detection of explosive compounds, and medical diagnosis. Gas chromatography mass spectrometry (GCMS) is the gold standard method for analysis of VOCs. However, these systems are bulky, expensive, and sophisticated laboratory instruments that require skilled professionals for operation. ProTech’s VOCSense is a sensor-based analysis technology that resembles the functionality of a gas chromatography mass spectrometry system. VOCSense can identify and quantify individual VOCs from normal air samples. ProTech is looking for a C-level leader and advisors to support them during development and fundraising.
CyloFlux is is unlocking the ability to passively store the "cold” during the winter to cool homes and buildings in the summer. Powering our homes, offices, schools, hospitals, restaurants, and stores consumes a lot of energy. Residential and commercial buildings account for approximately 40% of the nation’s total energy demand – greater than that for either industry (32%) or transportation (29%) – and about 75% of all electricity use (and even more of peak power demand). The resulting annual national energy bill for buildings totals over $410 billion. CyloFlux is developing a thermal diode that will unlock improved thermal energy storage technologies for applications in building energy efficiency. CyloFlux's heat pipe-based thermal diode is a dynamically tunable thermal energy transport material that allows rapid, directional transport of thermal energy - offering a potential 60% or grater savings in installation over ground source heat pumps (GSHPs).