CyloFlux is is unlocking the ability to passively store the "cold” during the winter to cool homes and buildings in the summer. Powering our homes, offices, schools, hospitals, restaurants, and stores consumes a lot of energy. Residential and commercial buildings account for approximately 40% of the nation’s total energy demand – greater than that for either industry (32%) or transportation (29%) – and about 75% of all electricity use (and even more of peak power demand). The resulting annual national energy bill for buildings totals over $410 billion. CyloFlux is developing a thermal diode that will unlock improved thermal energy storage technologies for applications in building energy efficiency. CyloFlux's heat pipe-based thermal diode is a dynamically tunable thermal energy transport material that allows rapid, directional transport of thermal energy - offering a potential 60% or grater savings in installation over ground source heat pumps (GSHPs).
Wearables are transforming how we exercise, train and perform. EXOForce Robotics is commercializing a groundbreaking high quality, stretch athletic textile that conforms to the body to enhance sensing performance, representing a substantial leap beyond current biometric offerings. These intelligent garments sense muscle behaviors and whole body biomechanics and use machine learning to tailor readouts to the wearer, quantify their workouts and alert them to impending injury. This technology has broad utility in the athletics (professional sports and consumer wellness), medical (rehabilitation and remote patient monitoring) and military markets. Ongoing R&D is focused on next-gen garments that both sense and intervene, and in the next few years will power everyday users to exercise their muscles while going about their tasks like walking their dog or running errands, provide postural corrections to prevent long-term pain or discomfort, and motivate those with sedentary lifestyles to get moving.
Rubitection is developing a skin health and wellness system to improve assessment and care management of dermatological, plastic surgery, and vascular conditions with an initial application to early bedsores detection. Bedsores are an $11 billion healthcare problem at affects 2.3 million each year killing 60K. If detected early they can be prevented, but low cost early detection tools are not available. Our Rubitect Assessment System (RAS) empowers any caregiver in hospitals, nursing homes, and in home care to detect bedsore early and support care management. Rubitection’s issued patents, and exclusive worldwide license provide barriers to competitors. The RAS’ low risk FDA pathway allows a quick path to a $4.1 billion US bedsore market. Two recurring revenues supports long term sustainability. Within 5 - 6 years of product launch, Rubitection will generate $48 million in sales using a hybrid sales model. Rubitection will exit through acquisition to a wound care company like Hill-Rom, or 3M.
geCKo Materials provides volume manufacturing for a bio-inspired, energy saving, reusable, multi-purpose, industrial and consumer adhesive. The mechanical adhesive is composed of directional, microscopic inclined features with a tapered geometry. geCKo’s unique IP is in the manufacturing method, introduced by Dr. Capella Kerst in her PhD at Stanford and protected by pending patents. Tested in the lab and in use with customers, a 1 square inch adhesive is capable of supporting 15 lbs of weight in shear with no attachment nor detachment force needed. The geCKo Opposing Force scales with area and can be purchased at any area. Integrating onto your robot grippers is simple, just a peel and stick. We can offer integration assistance and expertise for simple, quick and easy integration.
The logistics of ensuring compliance of thermal profiles (e.g., keeping cold items cold) for each product is a difficult problem. Solutions exist for monitoring temperature at coarse scale (shipping container), but those that precisely track each unit (color-changing stickers), lack the ability to precisely convey information in a scalable manner. Free Dynamics designs electronic temperature sensors that operate without any external batteries for months. Unlike current solutions, our quantum-mechanically-driven sensors are miniature and cost-effective enough to be incorporated into every vial of essential drugs that require stringent storage conditions. As a result, we can assure last-mile compliance while expecting higher accuracy. In addition, we have also shown that our system can be used for authentication which will guard the tagged assets against tampering and counterfeiting.
LEAH Labs is the first in the world using gene-editing to make a cure for cancer in dogs. We're building the first cure for canine cancer. It's called CAR-T cell therapy, and we know it works. CAR-T cells are FDA-approved and already saving human patients from their deathbeds in clinics today. This advance can only be made affordable for dogs because of our company's expertise in gene-editing technology.
Pharma companies have increasingly relied on innovative biotech startups to bolster their pipeline. The global small-molecule drug discovery market reached $25B in 2019 and is expected to grow to $50B by 2027. Think's business model is to partner with pharma companies to build precisely targeted, readily synthesizable molecules. For a drug target of interest, standard partnership models consist of an upfront fee with long-term development milestones and royalties. Just for the SHP2 (similar class to PTP1B) market, there have been several partnerships with deal values exceeding $500M. Synthetic biology is a growing field that designs microbes to confer capabilities outside their native function. Proof-of-concept has been demonstrated in elusive target, PTP1B, which is implicated in type 2 diabetes, obesity, and breast cancer. Further development will focus on optimizing the two novel drug scaffolds and expanding the platform to other key protein classes.
Palm Therapeutics is a San Diego based biotechnology startup, and member of JLABS@San Diego, in the early stages of development of an innovative class of drugs known as depalmitoylating molecules (DPALMs). The DPALM strategy was developed in the Devaraj Lab at The University of California San Diego by Dr. Andrew Rudd and Prof. Neal Devaraj. Our technology targets post-translational protein palmitoylation and represents a fundamentally new approach to inhibiting protein function. In preliminary studies, NRas-targeted DPALMs have shown in vitro and in vivo efficacy in NRas-driven melanoma models, and in September 2020, we were awarded a Phase I SBIR from NIH/NCI to pursue this indication.
Toragen Biotechnologies is focused on developing, repurposing and commercializing uniquely selective cancer drugs targeting cancers caused by the human papillomavirus (HPV). HPV associated cancers include Head and Neck Cancer, Cervical Cancer, and multiple other Genitourinary and Gastrointestinal Cancers. We are developing drugs designed to inhibit HPV oncogenes, the root cause of malignant transformation in these cancers. It is our intent that these drugs will be more selective for malignant cells and better tolerated by patients than traditional cytotoxic and radiation cancer therapy. Our drugs interfere with the ability of the HPV virus to inhibit the immune system and will thus enhance the ability of the immune system to eradicate these cancers and potentially augment the activity of existing immunotherapies for cancer.
Traumatic brain injury (TBI) contributes to approximately one-third of all injury-related deaths in the United States, with total direct and indirect costs estimated in excess of $76 billion. TBI is also the leading environmental risk factor associated with the development of chronic traumatic encephalopathy (CTE), a progressive degenerative disorder of the brain. Given the extensive public health burden, the lack of any approved therapies to modify the disease course for CTE continues to represent a critical unmet need. 3RT Innovations is a start-up founded in 2019 to address this need. We are currently developing a novel, brain penetrating antibody for the treatment of CTE. The neuropathology of CTE is characterized by abnormal aggregations of tau proteins in the neocortex with an organized filament structure comprised of three-repeat (3RTau) and four-repeat tau (4RTau). This organized filament structure is unique as it is found only in CTE and not in other tauopathies such as Alzheimer’s Disease.
The FloraPulse system is a microchip tensiometer (microtensiometer) that is embedded into the tree woody tissue and directly measures the water status, known as water potential. Because the measurement is taken directly inside the water-carrying tissue, readings are very accurate and reliable. You receive daily midday stem water potential readings, along with science-backed irrigation recommendations. Since 2017, we raised $1.2M in non-dilutive SBIR research awards to develop microT, and successfully field tested the product in almond, grape and prune commercial orchards and vineyards. In 2019-2020, we received $50k in customer deposits and sold the first 60 subscriptions ($90k) to 15 customers in the US, Chile and Australia. Customer feedback has been very positive. We are looking to hire a seasoned CEO to help the company raise funds, build partnerships, and continue increasing product sales in the US and abroad.
The labyrinth of jumbled blood vessels in the microenvironment of a solid tumor remains one of the toughest blockades for cellular therapies to penetrate and treat. For example, glioblastoma (GBM), the most common and aggressive type of brain cancer diagnosed in more than 22,000 Americans every year, is known for its prominent and abnormal vascularity and being immunologically "cold." Radix Therapeutics is developing immunotherapies to eradicate solid tumor cancers by targeting the tumor stroma, bridging the gap between current immunotherapies and drug-resistant cancers. Radix's improved immunotherapy combines chimeric antigen receptor (CAR) T cell therapy with selective inhibitors, enabling engineered cells to punch their way through and attack the tumor. Proof of concept has shown significantly enhanced survival in mice.
Pulmera enables x-ray visualization of the tracheobronchial tree to aid physicians in guiding endoscopic tools in the pulmonary tract. Early diagnosis and treatment are vital for improving lung cancer survival rates, and tissue biopsy is necessary for diagnosis. However, performing a lung biopsy is difficult due to the complexity of the highly branched airways of the lung, making it difficult to access and obtain the tissue and the procedure can pose a risk to the patient. Electromagnetic navigation bronchoscopy (ENB) is the safest way to obtain a biopsy but diagnostic success is limited by poor real time visualization of significant portions of the lung. Should the biopsy procedure be unsuccessful, patients may then need to have the tissue surgically removed. In a high number of these cases, the nodules are found to be benign. Pulmera will greatly improve the ability to obtain a diagnosis for the patient using ENB.
Based on engineering research conducted at UC Berkeley, H2Only’s patent-pending technology aims to revolutionize the way we produce water for agriculture. In terms of price point and scale, our technology was designed specifically for our customers: California almond farmers.
With the increase in obesity throughout the world, liver disease and nonalcoholic steatohepatitis (NASH)-related cancers are also increasing. Treatments are urgently needed to prevent the progression from nonalcoholic fatty liver disease (NAFLD) to NASH and hepatocellular carcinoma (HCC) via steatosis and fibrosis. Spectrin Bio aims to apply our siRNA therapy to treat obesity-associated nonalcoholic steatohepatitis (NASH) and liver cancer Our drug target is β-Spectrin (SPTBN1), a key player in both steatosis and fibrosis. Preclinical findings in mice (in vivo) and human 3D culture NASH model system have shown success in reducing body fat and lowering blood triacyl glycerol leves. Critically, siRNA therapies are already approved for diseases of the liver, blazing a trail for navigating regulatory approval.
The market for 5G applications is expected to grow significantly in the next decade. Major 5G players such as Qualcomm have traditionally used ASICs because of the economies of scale. However, there are a growing number of mid-sized companies that are developing FPGA solutions for 5G modems. The team has implemented FPGA blocks such as FFTs and FIR filters with less area, lower power, and shorter processing times. They also completed more than 130 Voice of Customer interviews with managers and engineers working in this area. The discussions and the feedback has validated the value of this technology in their area. During the discussions, the team identified companies as potential partners.
Nearly 1.6 million Americans have Type 1 Diabetes (T1D), an autoimmune class of diabetes. Additionally, ~3.2 million Americans develop latent autoimmune diabetes of adults (LADA). For T1D or LADA patients, immunotherapy promises a path to reprogram the immune system such that it no longer attacks and destroys insulin-producing beta cells in the pancreas. SermAb Biologics is developing a monoclonal antibody therapy against serpinB13. SermAb Biologics focuses on the discovery that tissue regeneration is stimulated by blocking serpinB13 and restoring the activity of its protease target. The second advantage is that our antibody to serpinB13 suppresses inflammation, increases beta-cell proliferation, and delays the onset of diabetes. Thus, by using a single reagent that regulates the balance between serpin inhibitor and protease, we can simultaneously suppress the inflammatory response while promoting regenerative changes in the pancreas and other tissues expressing serpinB13.
As part of a portfolio of COVID-19 inspired innovations aimed at advancing RNA vaccines and tools, Stanford researchers have developed a secured, invite-only version of their popular Eterna platform for designing mRNA vaccines. Eterna is an online application that integrates RNA folding algorithms, a video game interface, and associated computational methods to revolutionize vaccine design and RNA structure prediction. The new, secured version of the platform (called EteRNA Enterprise) is able to host selected participants to work in a confidential manner on problems such as designing improved mRNA vaccines that can be translated to clinical trials by industry partners and other collaborators. The data and designs generated by Eterna users may be used to develop improved mRNA vaccines immediately for the COVID-19 pandemic.
Current clinical diagnostic methods require confirmation by invasive procedures such as a biopsy of the gut, skin, or liver, while protein marker tests are limited to few tissue types and do not detect infections. Short fragments of cell-free DNA circulate in blood, urine and other biofluids and offer an information-rich window into human physiology, with rapidly expanding applications in prenatal testing, cancer screening, organ transplant monitoring and infectious disease testing. Our research pursues technologies and applications of cell-free DNA in infectious and immune-related disease.
One of the most worrisome complications of the current global pandemic of COVID-19 is acute respiratory distress syndrome (ARDS), which is characterized by excess inflammation and fluid in the lung and has high mortality despite years of study. Research has indicated that more than 40% of the individuals hospitalized with severe COVID-19 develop ARDS and over half of those cases are fatal. A team of researchers at the University of Minnesota with decades of research knowledge surrounding lung diseases have developed a novel and promising treatment approach for ARDS utilizing Liothyronine (T3), a synthetic form of thyroid hormone that already has FDA approval. Application of T3 to injured lungs has been shown to speed fluid clearance in animal models and clinical trials are already underway to validate translation to humans suffering with ARDS.
Optic neuropathies are a group of optic nerve diseases characterized by the progressive death of RGCs and optic nerve degeneration. Optic neuropathy is the most common clinical cause of irreversible blindness. There is no effective neuroprotective treatment to prevent RGC/optic nerve degeneration. Genes involved in RGC signaling have been found to play roles in RGC/optic nerve degeneration and thus serve as potential gene therapy targets. However, before effective gene therapies can be developed a method to specifically target the RGCs is needed.
Neurodegenerative diseases are a large group of progressive and eventually fatal diseases of the central nervous system (CNS). These diseases – including Alzheimer’s disease, Parkinson’s diseases, amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), and Huntington’s disease – are taking an increasingly heavy toll on individuals and the society as the human population ages, yet they remain incurable. Evergreen seeks to develop novel therapies for several neurodegenerative diseases based on AAV-mediated gene transduction.
The scientific community is continuously trying to improve their understanding of genetic mechanisms in biological systems and finding biomarkers for diagnosis, prognosis and treatment. With growing accessibility, still, only the minority of investigators in the life and medical sciences has the means to analyze and leverage this enormous treasure of data. Bioada is an integrated, easy to use and interactive genomics data analysis platform for the broader community of life scientists.
Conventional electronic devices based on flexible or rigid printed circuit boards (PCBs) cannot conform to curved surfaces or stretch to accommodate new requirements of disruptive technologies. Additionally, existing methods for the production of stretchable electronics are unable to produce devices with high integration densities achievable with conventional methods. These methods also rely on processes that cannot be implemented at scale. This technology overcomes these limitations and enables practical applications of stretchable electronic devices for health monitoring, wearable computing, medical devices, and beyond.
VDIs cannot protect sensitive data unless remote users can securely operate the VDI client on their computers. If users’ computers are compromised, hackers can screen capture and view confidential data on VDI servers, and sniffer users’ keystrokes (e.g., passwords), etc. Attackers gain same VDI data access as users despite perfect network and VDI server security. Most existing products are insecure, because they assume commodity OSes (e.g., Windows 10, Mac OS) and applications have no security flaws. Other products violate users’ experiences as they cannot run user-chosen applications locally to process insensitive data. In short, no usable secure VDI client exists to-date. We built *the only usable secure VDI client*. Our on-demand isolation technique protects users’ operations even when OS and users’ locally installed tools are compromised, and maintains users’ experience. Also, our solution eliminates IT admin labor to maintain VDI client security.
Our ultimate goal is to develop novel small molecule, broad-spectrum therapeutics against viral infections caused by filoviruses, arenaviruses, rhabdoviruses, and others that depend on the PPxY L-domain motif for virus egress and spread of infection. Some of these viruses, including Ebola (EBOV), Marburg (MARV), and Lassa fever (LAFV) viruses, are highly pathogenic and classified as Category A, bioterror pathogens. Importantly, we have identified an analog capable of blocking in vivo activity in a Marburg virus challenged mouse model, providing essential proof of concept for this novel class of anti-viral therapeutics. We predict that the novel class of anti-viral products targeting EBOV, MARV, and LAFV will be used for treatment of infected individuals as well as in prophylactic treatment of soldiers, healthcare workers, or others at high risk. Emergency administration of such an antiviral therapeutic during an outbreak could potentially inhibit virus dissemination in infected individuals.
We treat faces as if they were feet, and that’s absurd. Unlike feet, faces are 3D, yet we still measure them using 2D objects such as paper cutouts in the massive $6b market to fit people with masks. This doesn’t cut it, and the data backs it up: 50% of Americans don’t wear the CPAP masks they’ve been prescribed because of these fit, comfort, and convenience issues. The only reason we’ve tolerated this is that until recently there has been no better way to get good 3d measurements of your face without lots of specialized tools. We solve this problem by making it as easy as taking a selfie to get precise 3D measurements of your face.
Dr. Xiaoyang Zhu’s research team at Columbia University developed a method for high-yield production of macroscopic 2D materials. The technique produces macroscopic 2D materials that are comparable in quality to microscopic monolayers formed by Scotch tape exfoliation, with the significant advantage of achieving high-yield production. This technology has potential to catalyze manufacturing of 2D materials such as graphene and transition metal dichalcogenide monolayers for use in many applications.
Seven Biosciences is a GPCR targeted drug discovery company which engineers and uses cutting-edge technology. Seven’s proprietary technology are fluorescent sensors based on any GPCR, which enables the functional visualization of the conformational change of the receptor in response to the binding of a given compound in real-time. The technology can be used for high throughput screening of compound libraries against GPCR targets, including orphan GPCRs, as well as for profiling the physiologically relevant effects of candidate molecules. Additionally, Seven’s GPCR sensors can be expressed in vivo –enabling the monitoring of compound effects at the site of action in awake behaving animals and in disease models undergoing treatment with unmatched spatial and real-time temporal resolution.
MedGyde develops ligand and antibody directed products which bind to antigens specific to various cancer subtypes. MedGyde’s pipeline includes antibodies and single-chain variable fragments which have demonstrated cytotoxic properties. The products have therapeutic as well as diagnostic applications (theranostic). MedGyde has also developed a radio-sensitization technology that targets and sensitizes cancer cells. The lead therapeutic antibody to inducible neoantigen, TIP1, binds specifically to cancer. It has been conjugated to both radiopharmaceuticals and chemotherapy which markedly improved cancer cures in pre-clinical cancer models. The planned clinical trial will be in patients with advanced non-small cell lung cancer. MedGyde has been awarded several NIH small business grants to further develop antibodies and nanoparticle drug delivery systems. Venture capital is needed for GMP manufacturing and IND enabling safety testing.
Keidar PlasmaTech aims to apply our non-invasive cold plasma device to treat brain tumors. The scientific leaders have complementary bench and clinical expertise that has enabled both understanding of the mechanisms of action of cold plasma to selectively kills cancer cells and the development of a plan to reach human patients in just 1 year.
OT Bio aims to apply our patented intranasal oxytocin therapy to treat sleep apnea and protect patients from associated heart disease. The scientific leaders have complementary bench and clinical expertise that has enabled both understanding of oxytocin's mechanisms in the brain and human studies showing improved respiratory and cardiac functions.
Nanopath has developed a platform for rapid, point-of-care biomarker purification and characterization from a patient sample. Our technology was originally developed at Dartmouth College as part of our PhD research, and is using advances in bioengineering and nanotechnology to reduce noise and improve signal in diagnostic systems. This allows for an integrated system that takes a complex patient sample, isolates key biomarkers, and analyses them without the need for lengthy clinical workflows. We believe that this new diagnostic paradigm has applications to a range of disease indications including bloodstream infections, cancer liquid biopsy, urinary tract infections, respiratory infections, and wound infections.
Long gap peripheral nerve injuries (i.e., gaps >3cm) remain a clinical challenge. When there is a long gap nerve injury, the standard of care is transplanting a nerve from one place in the body to the area where the defect is, a technique known as autografting. The use of an autograft requires a second surgical site resulting in longer operating times, and typically a sensory nerve is used to replace a motor/sensory nerve, which leaves an area of the body with permanent numbness. There are a handful of nerve guides on the market available to regenerate nerve gaps less than 1 inch. However, there are no synthetic guides available having an FDA-approved indication for use in nerve gaps greater than one inch. Our patented technology utilizes a biodegradable tube containing a controlled drug delivery system supplying the cues necessary to promote the growth of nerves over large gaps, thus fulfilling this clinical unmet need.
Stork.ai is leveraging its strong foundations in reproductive medicine, big data, and artificial intelligence to create next-generation fertility products that ultimately help people have babies. It is commercializing a decision assessment tool comprised of patent-pending, AI-based software (“STORK”) that reliably assesses embryo (blastocyst) quality. STORK was developed using a proprietary, multi-focal embryo image dataset from Weill Cornell’s Center for Reproductive Medicine. STORK can also predict genetic defects such as aneuploidy, which involves an abnormal number of chromosomes in the embryo.
Cognivive develops FDA-registered, personalized, evidence-based, prescription digital therapeutics used by patients at home to treat neuromotor and neurocognitive impairments resulting from stroke.
Gateway Bio is developing an innovative “PEG-like” drug conjugation technology that eliminates the antigenicity issues surrounding PEGylation today. Gateway Bio was specifically formed to translate several scientific breakthroughs from the lab of Professor Chilkoti at Duke University into commercially viable products and processes by combining the expertise of the academic scientists closest to these technologies with the business acumen of experienced start-up professionals. The initial core technology of Gateway Bio is based on several key patents on POEGMA conjugates that have been successfully licensed from Duke by Gateway Bio. Our novel method of creating PEG-like conjugates could be applied to generics, existing drugs, newly developed drugs or any of the PEGylated pharmaceuticals currently on the market. There are currently 15 FDA-approved peglyated drugs, with dozens more in clinical trials. Sales of the two most successful pegylated products, Pegasys and Neulasta, exceeded $5 billion in 2011.
Spirair is addressing the unmet need for a minimally-invasive, office-based treatment for NSD. While there is high demand among ENT physicians for office-based procedures (e.g. Acclarent, Arrinex, Spirox, etc), NSD is one of the few common pathologies that does not have any office-based innovations. Spirair is filling this gap in the marketplace with a needle-based delivery device that correction NSD with local anesthetic in under 15 minutes. The estimated US/European TAM is $2.3B. Spirair will be regulated under a 510(k) pathway, and FDA clearance can be achieved by 2023 with minimal clinical data (30 patients, 6 months of follow-up).
Ever since the advent of robot‐assisted surgery in 1985, the value of using robotic systems to assist in surgical procedures in the modern operating theatre has been demonstrated repeatedly. However, most intraocular surgical procedures continue to be performed manually by surgeons. One of the most common procedures is cataract surgery, which is performed approximately 2.5 million times a year in the United States alone. The team has developed a novel robotic system — the IRISS— aimed at remotely operated and fully automated intraocular mechanical manipulations and therapeutic surgery.
In orthopaedic surgery, procedures commonly include fixation of bone and soft tissues. Currently, surgical manipulation of these bones and soft tissues is accomplished by the application of manual force either directly on tissue or through devices that transmit forces to the tissue including pins, screws, bolts, straps, and clamps. These methods of performing orthopaedic surgery have several disadvantages: Manual force is limited by the strength and endurance of the surgeon and surgical assistants, manual manipulation has limited precision, reliance on manual manipulation exposes the surgeon and surgical assistants to increased radiation exposure when intra-operative fluoroscopy is used to confirm position during manipulation of bone. ARTS is developing the Robotic Surgical Assist Arm (RSAA), a motorized rigid traction system which standardizes and facilitates the correct placement of the bones. Focusing on long bone repair the initial market would be in the area of 100,000 cases annually in America.
The Tissue Oracle addresses an unmet need to identify which regions of excised breast tissue should undergo histopathological assessment to diagnose breast disease. Our envisioned product deploys optical coherence tomography (OCT) imaging and artificial intelligence image analysis to achieve the microscopic-level resolution, large field of view, and fast throughput necessary for integration into clinical workflow. The value proposition is that our image-guided sample selection can reduce the number of tissue blocks submitted for histopathology, and the associated cost and workload, by 30-50%. The target customers are pathologists and administrators seeking greater efficiency for a key step in breast cancer care.
Fungal bioproduction makes up 50% of the industrial enzymes market, a $10B market with a CAGR of 7.1% yearly. Fungal production of enzymes requires that large, dense cultures of cells be aerated properly. Dense cultures, however, become very viscous; stirring these cultures to provide oxygen can damage cells. Aethergen introduces mutations into fungi which convey morphology beneficial for fermentation processes, and lower oxygen consumption by half. This alleviates the need for a tradeoff between culture density and oxygen transfer. Aethergen can thus offer both enzyme manufacturers and strain improvement companies a more efficient process, lowering raw material costs and increasing margins.
There are 230 million surgeries performed per year worldwide. Surgical experience is the primary factor dictating outcome of each operation. However, surgical experience is not quantifiable, not accessible as a data source, and not easily distributable between users. This leads to variability in outcomes, complications, inefficiency, and high costs in surgical care delivery. What if an artificial intelligence (AI) platform could be designed that would quantify and learn from surgical experience, then customize and distribute tailored information back to all surgeons in real-time?
Researchers at Stanford have developed a new water-based disinfectant with the potential to destroy a wide variety of pathogens and significantly improve healthcare settings. AquaROS, a novel and broad-spectrum disinfectant, is based on the formation of micron-sized water droplets that cause the spontaneous generation of highly reactive oxidant species (ROS). Access to safe and effective disinfecting solutions like AquaROS is more critical than ever – in the U.S. approximately the same number of people die from healthcare-associated infections (HAIs) as from AIDS, breast cancer and auto accidents combined. Inexpensively produced by atomizing water, the new disinfectant has been shown to outperform other commercial methods at inactivating Salmonella typhimurium and E. coli. Based on these and other promising results, the researchers anticipate AquaROS can kill bacteria, fungi, mycobacteria and bacterial spores on critical surfaces such as medical instruments.
Zeit Medical develops a platform health monitoring technology that enables continuous neurophysiological assessment for a wide gamut of neurological diseases affecting Americans of all ages. Our first target is stroke (severe cerebral ischemia). Stroke is a devastating disease. In the United States alone, it is the leading cause of long-term disability and cognitive impairment, as well as the fifth leading cause of death. Someone in the United States suffers a stroke every 40 seconds and an estimated $72 billion are being spent annually on direct medical care of stroke patients. Our alert system is capable of reliably recognizing neurological events within minutes and alerts the patients, caregivers and 911.
Working men and women lift every day. They do it in warehouses and on production lines. In offices and combat zones. Every day, they lift the economy worldwide. Whether it’s the day-to-day grind or responding to a crisis, their strength supports us all. And they deserve gear that sustains their strength, for work and for life. That makes their job safer. The HeroWear Apex means that their weight is over. The world’s first exosuit for all, built from the ground up for both men and women, the Apex is a back-assist exosuit that uses a proprietary band-based mechanism to reduce strain on the back without getting in the way.
Using patent-pending technology developed at Vanderbilt University, our technique overcomes cost and scaleability limitations associated with traditional manufacturing techniques, while also giving commercial viability to carbon conversion technologies through the introduction of a high-value secondary material produced from greenhouse gas inputs. Our technique relies on electrochemistry, rather than solely catalysis, and results in a highly efficient process to convert atmospheric carbon dioxide into useful functional nanomaterials.
The human immune system participates in complex interactions with virtually all other systems in the body. In particular, the B-cell component of the adaptive immune response plays a role in various disease settings, including infectious disease, cancer, autoimmunity, cardiovascular, hematologic, neurologic diseases, and others. In addition, antibodies (a product of B cells) are effectively used in diagnostics, therapy, and prevention. To address these significant challenges with current technologies for B cell characterization and antibody discovery, we recently developed a novel technology that, for a given sample, enables the mapping of antibody sequence to antigen specificity from a single high-throughput experiment for a large number of antigens and B cells at a time.
With Gates Foundation funding, Dr. Larry Zwiebel at Vanderbilt University has created a powerful insect repellant technology that repels all insects. Testing, so far, indicates no adverse affects to people, animals or the environment. Vanderbilt is forming a company to commercialize the technology. The first field for which the company will develop a product is the facility perimeter treatment market in the US. This includes homes, buildings and other structures. The annual market for the perimeter treatment products (without service cost) is about $10 billion. The annual growth of the market is about 4%, and the demand growth is considerably higher for products that are "green".
Designer biopolymers have numerous biotech applications due to their superior specificity and efficacy. However, their large size and complexity hindered the development of effective engineering methods, leaving developers with suboptimal molecules. This is most prevalent in drug discovery and diagnostics: patients routinely develop strong adverse reactions to biologics (e.g., many SARS-CoV-2 IgG tests have weaker specificity and affinity, leading to dubious results). Optimer is changing the status quo through its hybrid computational and experimental biopolymer engineering platform capable of designing DNA, RNA, and proteins with superior properties - especially target activity and specificity - for a broad range of biotech solutions. Optimer is currently rigorously testing and aggressively pursuing patent protection for its methodology and won a pilot award from Columbia’s Translational Therapeutics (TRx) Lab-to-Market accelerator program.