Detecting and quantifying very low concentrations of disease biomarkers is important for the diagnosis and management of many disease conditions in their early phases. Technologies to detect low concentrations of biomarkers are only available in the advanced research or central clinical laboratories, due to high technology complexity and costs causing significant delay in reaching correct diagnosis. Instanosis testing platform enables ultrasensitive, low-cost and rapid quantitation of disease biomarkers. This platform has many applications in multiple instances, where rapid, convenient and ultra-sensitive biomarker detection is crucial for disease detection and treatment. The lead application is the ultrasensitive detection of SARS-CoV-2 antigen in the community setting using smartphones. Current diagnostic gold standard for SARSCoV- 2 is rRT-PCR, which requires expensive extraction instrument, thermocycler, facilities and trained operators to conduct and hours or days to turn around results.
Smell loss is an early indicator of infectious and neurodegenerative disorders. In COVID-19, for example, objective smell loss may occur in >90% of patients. Though molecular (PCR) tests are effective in diagnosing SARS-CoV-2 infection, with moderate sensitivity and high specificity, they typically are costly (>$50), with long turnaround times (up to 5-7 days) and have not been as effective in controlling asymptomatic spread. The Aromha Smell Test complements molecular tests with high sensitivity and negative predictive value and can be scaled quickly to provide an important new tool to prevent community spread of COVID, with an at-home, non-invasive, safe, and cost-effective screening test that provides instantaneous results. This platform technology, developed based on 20 years of olfactory research at Harvard, can also be utilized to provide an early signal and improve care in critical neurodegenerative diseases such as Alzheimer's, Parkinson's Disease, and Traumatic Brain Injury.
IMIJ Technologies is a startup from the labs of Columbia’s Dr. Scott Small and Dr. Frank Provenzano that focuses on novel approaches to broad neurological and psychiatric screening and diagnostics that can be applied to existing and conventional neuroimaging - structural MRI. IMIJ has successfully developed and adapted technologies initially researched at Columbia to a variety of existing conventional neuroimaging to develop statistically rigorous candidate biomarkers, as well a fully interpretable report detailing the results. IMIJ uses the same images frequently obtained to diagnose brain diseases, images acquired tens of millions of times a year in the US alone. IMIJ's proprietary software requires no additional data or MRI equipment. IMIJ has raised $1.1M seed funding to date and is seeking $9M with the goal of securing approval for indication in order to refine the development and pilot with a major hospital system.
PrevPanc is developing an improved prophylactic against pancreatitis caused by endoscopic retrograde cholangiopancreatography (ERCP), by targeting two key inflammatory pathways. Post-ERCP pancreatitis can be life-threatening, excruciatingly painful, and costly. PrevPanc is developing a more effective and practical treatment to prevent pancreatitis, with significant improvements beyond current options of indomethacin, stenting, and IV hydration. PrevPanc's therapy is a combination of a calcineurin inhibitor combined with indomethacin to target two distinct inflammatory pathways, achieving higher effectiveness than the current standard of care with minimal change in post-procedure care.
SmartScan2 is revolutionizing secure identification applications with unclonable polymer film-based, scalable technology. Most, if not all security devices in use today can be corrupted, counterfeited, or easily interpreted. Examples of these devices include personal identification cards, passports, pharmaceutical product tracking, currency, and product identification tags. One good example of this corruption involves credit cards. The fifty year old “magnetic strip” technology on a credit card has been corrupted by the use of illegal credit card “skimmers” attached to the credit card readers, and reported in the local news as prevalent on gas pumps and ATMs. The newer “chip” technology on credit cards can also be corrupted by the use of credit card skimmers which are becoming more prevalent in similar locations. SmartScan2's ID security is “unclonable” since it is vastly more difficult to corrupt, counterfeit or interpret the relevant information.
For low-resource internet-of-things (IoTs) like wearables, health-monitors, tags and sensors, existing authentication techniques (e.g., encryption, strong hash functions, pseudorandom number generators) might be impractical for securing access to critical data. This is because these devices have limited computational bandwidth; limited energy; and require real-time authentication. Static identifiers like bar-codes, product IDs, embedded physical unclonable functions (PUFs) or stored private keys are vulnerable to theft, counterfeiting, replay attacks or tampering. In this gap, Secure Dynamics is delivering enterprise-grade security solutions for energy-constrained Internet-of-things using zero-power timers. This solution uses zero-power timers to generate dynamic tokens that are secure against any power side-channel attacks, eaves-dropping and tampering. The hardware-software solution also supports mutual authentication, where the IoT device could also query and verify the trust of its reader.
Microchips used in pet care today focus on providing proof of ownership and access to medical records in an emergency. But these microchips are an opportunity to provide better care to our companions. Chipped is a venture backed startup focused on bringing continuous monitoring of key metabolites of interest in the pet health space to pet owners and veterinary care staff. The first metabolites of interest are glucose and uric acid. Additionally, body temperature can be monitored from the same implantable (chip-based) device for long term monitoring of cat and dog health. An app based interface is coupled with the chip to provide full pet care monitoring. Chipped is seeking a CEO to lead the way toward transforming the companion animal and pet care market.
Transfoam harnesses engineered microorganisms and renewable feedstocks to tackle plastic pollution at the beginning and end of the product lifecycle. Our proprietary bioprocess reduces the operating cost and environmental footprint of PHB manufacturing to overcome limitations currently hindering the industry’s growth. Plastic is at the forefront of our transition to a circular economy. We treat plastic waste as a valuable resource rather than a burden. By using a waste-based feedstock, we can both remove plastic pollution from the environment and provide a safe, accessible alternative. Polyhydroxybutrayte (PHB) is a bio-based polymer with similar properties as many traditional single-use plastics, except it degrades fully in the environment. PHB is both produced and consumed by microorganisms, leaving behind only traces of water and CO2 after use/disposal.
Stanford researchers led by Stephen Tsai are advancing a new, much simplified design approach for composite laminates – termed "double-double" – that can replace conventional laminates for lighter, tougher, and lower cost airplane structures among other uses. Whereas legacy quad laminates have remained static since their development in the 1960s and are becoming so complex that have added time and cost in their use. They are no longer optimal. Double-double laminates simplify optimization, leading to new structures with unmatched low weight and cost. As a result, the double-double composite structures can be designed and produced with tapers to save weight, to have ply drops on the exterior surface to remove defects from the interior, and 1-axis layup of multi-axial tape and fabric —in a customizable manner—meet requirements of many applications, from heavily loaded aircraft wings to sports products. Double-Double Materials is looking partners to help build this venture opportunity along with Prof. Tsai.
VitalCore is a Medical Devices Integration (MDI) solution that provides an integrated platform for showing the status, error messages, and patient info stored across all devices in various hospitals. VitalCore provides a visualized form of status data for easier comprehension and viewership by using tables, bar graphs, line charts, pie charts, and donut charts that enable the users to grasp the trend of the data and generate insights efficiently to improve patient care and reduce costs. Compared to similar device connectivity monitoring providers, VitalCore is focused on medical devices and has an active pilot that provides both an HL7 viewer and mobile application for healthcare professionals on the go. VitalCore is looking to expand their leadership team as they prepare to fundraise.
Functional brain imaging is an important tool to assess brain health in conditions like stroke, cognitive function, visual function disorders, Parkinson’s, and ischemia. However, the MRI scanners are too bulky and expensive to bring the assessment where it is needed at the bedside or in ambulatory settings. EsperDyne's Wearable Optical Brain Imaging (WOBI) system addresses the cost and portability gap, bringing affordable functional brain imaging to the bedside and beyond. The market size for fNIRS Brain Imaging Systems is currently estimated at more than $135M with a CAGR of 10% as the systems gain additional research and clinical importance. The two known competing research systems lack the voxel density and portability of the WOBI system. The WOBI technology is protected by two issued and two pending US patents and has 3 prototype generations.
Celata is the first company leveraging transomics data and machine learning to see what others do not. We provide answers to crucial questions across drug discovery from target ID to patient selection. Our approach yields actionable and unbiased results based on data that meets three fundamental principles: (1) global, (2) dynamic, and (3) contextual.
Viral infections causing hepatitis are major contributors to human morbidity and mortality. Currently, there are no approved directly acting antivirals that cure two of these viruses - hepatitis B (HBV) and E viruses (HEV) – that account for close to 300 million infections world-wide. Our goal is to develop novel small molecule therapeutics that can be readily deployed to combat efficiently these diseases. To achieve this, we capitalize on discoveries and technical advances from our lab that put us in a unique position for targeted high through-put screens. We have already identified a lead molecule that is effective against multiple HEV genotypes, and we have uncovered a minimal set of host factors that are essential for HBV persistence.
Antimicrobial resistance is emerging as a growing global threat. Currently, more than 10 million people per year become infected by drug-resistant bacteria and those numbers are predicted to grow exponentially in the coming years. There is thus a pressing need for new antibiotics, and in particular for antibiotics with novel mechanisms of action. To address this need we have developed a novel pipeline for rapidly determining the mechanism of action of candidate antibiotics. With this approach we can fundamentally change the traditional antibiotic discovery pipeline by focusing our efforts on compounds with novel mechanisms of action (instead of the traditional efforts that prioritize based on chemical features and efficacy, leading to the rediscovery of similar compounds time and time again).
Volatile organic compounds (VOCs) are carbon containing molecules that have low boiling points and high vapor pressures causing them to evaporate into gas phase at ambient conditions. A wide range of VOC analysis devices are used in various industries for occupational exposure monitoring, environmental monitoring, process control, detection of explosive compounds, and medical diagnosis. Gas chromatography mass spectrometry (GCMS) is the gold standard method for analysis of VOCs. However, these systems are bulky, expensive, and sophisticated laboratory instruments that require skilled professionals for operation. ProTech’s VOCSense is a sensor-based analysis technology that resembles the functionality of a gas chromatography mass spectrometry system. VOCSense can identify and quantify individual VOCs from normal air samples. ProTech is looking for a C-level leader and advisors to support them during development and fundraising.
CyloFlux is is unlocking the ability to passively store the "cold” during the winter to cool homes and buildings in the summer. Powering our homes, offices, schools, hospitals, restaurants, and stores consumes a lot of energy. Residential and commercial buildings account for approximately 40% of the nation’s total energy demand – greater than that for either industry (32%) or transportation (29%) – and about 75% of all electricity use (and even more of peak power demand). The resulting annual national energy bill for buildings totals over $410 billion. CyloFlux is developing a thermal diode that will unlock improved thermal energy storage technologies for applications in building energy efficiency. CyloFlux's heat pipe-based thermal diode is a dynamically tunable thermal energy transport material that allows rapid, directional transport of thermal energy - offering a potential 60% or grater savings in installation over ground source heat pumps (GSHPs).
Wearables are transforming how we exercise, train and perform. EXOForce Robotics is commercializing a groundbreaking high quality, stretch athletic textile that conforms to the body to enhance sensing performance, representing a substantial leap beyond current biometric offerings. These intelligent garments sense muscle behaviors and whole body biomechanics and use machine learning to tailor readouts to the wearer, quantify their workouts and alert them to impending injury. This technology has broad utility in the athletics (professional sports and consumer wellness), medical (rehabilitation and remote patient monitoring) and military markets. Ongoing R&D is focused on next-gen garments that both sense and intervene, and in the next few years will power everyday users to exercise their muscles while going about their tasks like walking their dog or running errands, provide postural corrections to prevent long-term pain or discomfort, and motivate those with sedentary lifestyles to get moving.
Rubitection is developing a skin health and wellness system to improve assessment and care management of dermatological, plastic surgery, and vascular conditions with an initial application to early bedsores detection. Bedsores are an $11 billion healthcare problem at affects 2.3 million each year killing 60K. If detected early they can be prevented, but low cost early detection tools are not available. Our Rubitect Assessment System (RAS) empowers any caregiver in hospitals, nursing homes, and in home care to detect bedsore early and support care management. Rubitection’s issued patents, and exclusive worldwide license provide barriers to competitors. The RAS’ low risk FDA pathway allows a quick path to a $4.1 billion US bedsore market. Two recurring revenues supports long term sustainability. Within 5 - 6 years of product launch, Rubitection will generate $48 million in sales using a hybrid sales model. Rubitection will exit through acquisition to a wound care company like Hill-Rom, or 3M.
geCKo Materials provides volume manufacturing for a bio-inspired, energy saving, reusable, multi-purpose, industrial and consumer adhesive. The mechanical adhesive is composed of directional, microscopic inclined features with a tapered geometry. geCKo’s unique IP is in the manufacturing method, introduced by Dr. Capella Kerst in her PhD at Stanford and protected by pending patents. Tested in the lab and in use with customers, a 1 square inch adhesive is capable of supporting 15 lbs of weight in shear with no attachment nor detachment force needed. The geCKo Opposing Force scales with area and can be purchased at any area. Integrating onto your robot grippers is simple, just a peel and stick. We can offer integration assistance and expertise for simple, quick and easy integration.
The logistics of ensuring compliance of thermal profiles (e.g., keeping cold items cold) for each product is a difficult problem. Solutions exist for monitoring temperature at coarse scale (shipping container), but those that precisely track each unit (color-changing stickers), lack the ability to precisely convey information in a scalable manner. Free Dynamics designs electronic temperature sensors that operate without any external batteries for months. Unlike current solutions, our quantum-mechanically-driven sensors are miniature and cost-effective enough to be incorporated into every vial of essential drugs that require stringent storage conditions. As a result, we can assure last-mile compliance while expecting higher accuracy. In addition, we have also shown that our system can be used for authentication which will guard the tagged assets against tampering and counterfeiting.
LEAH Labs is the first in the world using gene-editing to make a cure for cancer in dogs. We're building the first cure for canine cancer. It's called CAR-T cell therapy, and we know it works. CAR-T cells are FDA-approved and already saving human patients from their deathbeds in clinics today. This advance can only be made affordable for dogs because of our company's expertise in gene-editing technology.
Pharma companies have increasingly relied on innovative biotech startups to bolster their pipeline. The global small-molecule drug discovery market reached $25B in 2019 and is expected to grow to $50B by 2027. Think's business model is to partner with pharma companies to build precisely targeted, readily synthesizable molecules. For a drug target of interest, standard partnership models consist of an upfront fee with long-term development milestones and royalties. Just for the SHP2 (similar class to PTP1B) market, there have been several partnerships with deal values exceeding $500M. Synthetic biology is a growing field that designs microbes to confer capabilities outside their native function. Proof-of-concept has been demonstrated in elusive target, PTP1B, which is implicated in type 2 diabetes, obesity, and breast cancer. Further development will focus on optimizing the two novel drug scaffolds and expanding the platform to other key protein classes.
Palm Therapeutics is a San Diego based biotechnology startup, and member of JLABS@San Diego, in the early stages of development of an innovative class of drugs known as depalmitoylating molecules (DPALMs). The DPALM strategy was developed in the Devaraj Lab at The University of California San Diego by Dr. Andrew Rudd and Prof. Neal Devaraj. Our technology targets post-translational protein palmitoylation and represents a fundamentally new approach to inhibiting protein function. In preliminary studies, NRas-targeted DPALMs have shown in vitro and in vivo efficacy in NRas-driven melanoma models, and in September 2020, we were awarded a Phase I SBIR from NIH/NCI to pursue this indication.
Toragen Biotechnologies is focused on developing, repurposing and commercializing uniquely selective cancer drugs targeting cancers caused by the human papillomavirus (HPV). HPV associated cancers include Head and Neck Cancer, Cervical Cancer, and multiple other Genitourinary and Gastrointestinal Cancers. We are developing drugs designed to inhibit HPV oncogenes, the root cause of malignant transformation in these cancers. It is our intent that these drugs will be more selective for malignant cells and better tolerated by patients than traditional cytotoxic and radiation cancer therapy. Our drugs interfere with the ability of the HPV virus to inhibit the immune system and will thus enhance the ability of the immune system to eradicate these cancers and potentially augment the activity of existing immunotherapies for cancer.
Traumatic brain injury (TBI) contributes to approximately one-third of all injury-related deaths in the United States, with total direct and indirect costs estimated in excess of $76 billion. TBI is also the leading environmental risk factor associated with the development of chronic traumatic encephalopathy (CTE), a progressive degenerative disorder of the brain. Given the extensive public health burden, the lack of any approved therapies to modify the disease course for CTE continues to represent a critical unmet need. 3RT Innovations is a start-up founded in 2019 to address this need. We are currently developing a novel, brain penetrating antibody for the treatment of CTE. The neuropathology of CTE is characterized by abnormal aggregations of tau proteins in the neocortex with an organized filament structure comprised of three-repeat (3RTau) and four-repeat tau (4RTau). This organized filament structure is unique as it is found only in CTE and not in other tauopathies such as Alzheimer’s Disease.
The FloraPulse system is a microchip tensiometer (microtensiometer) that is embedded into the tree woody tissue and directly measures the water status, known as water potential. Because the measurement is taken directly inside the water-carrying tissue, readings are very accurate and reliable. You receive daily midday stem water potential readings, along with science-backed irrigation recommendations. Since 2017, we raised $1.2M in non-dilutive SBIR research awards to develop microT, and successfully field tested the product in almond, grape and prune commercial orchards and vineyards. In 2019-2020, we received $50k in customer deposits and sold the first 60 subscriptions ($90k) to 15 customers in the US, Chile and Australia. Customer feedback has been very positive. We are looking to hire a seasoned CEO to help the company raise funds, build partnerships, and continue increasing product sales in the US and abroad.
The labyrinth of jumbled blood vessels in the microenvironment of a solid tumor remains one of the toughest blockades for cellular therapies to penetrate and treat. For example, glioblastoma (GBM), the most common and aggressive type of brain cancer diagnosed in more than 22,000 Americans every year, is known for its prominent and abnormal vascularity and being immunologically "cold." Radix Therapeutics is developing immunotherapies to eradicate solid tumor cancers by targeting the tumor stroma, bridging the gap between current immunotherapies and drug-resistant cancers. Radix's improved immunotherapy combines chimeric antigen receptor (CAR) T cell therapy with selective inhibitors, enabling engineered cells to punch their way through and attack the tumor. Proof of concept has shown significantly enhanced survival in mice.
Pulmera enables x-ray visualization of the tracheobronchial tree to aid physicians in guiding endoscopic tools in the pulmonary tract. Early diagnosis and treatment are vital for improving lung cancer survival rates, and tissue biopsy is necessary for diagnosis. However, performing a lung biopsy is difficult due to the complexity of the highly branched airways of the lung, making it difficult to access and obtain the tissue and the procedure can pose a risk to the patient. Electromagnetic navigation bronchoscopy (ENB) is the safest way to obtain a biopsy but diagnostic success is limited by poor real time visualization of significant portions of the lung. Should the biopsy procedure be unsuccessful, patients may then need to have the tissue surgically removed. In a high number of these cases, the nodules are found to be benign. Pulmera will greatly improve the ability to obtain a diagnosis for the patient using ENB.
Based on engineering research conducted at UC Berkeley, H2Only’s patent-pending technology aims to revolutionize the way we produce water for agriculture. In terms of price point and scale, our technology was designed specifically for our customers: California almond farmers.
With the increase in obesity throughout the world, liver disease and nonalcoholic steatohepatitis (NASH)-related cancers are also increasing. Treatments are urgently needed to prevent the progression from nonalcoholic fatty liver disease (NAFLD) to NASH and hepatocellular carcinoma (HCC) via steatosis and fibrosis. Spectrin Bio aims to apply our siRNA therapy to treat obesity-associated nonalcoholic steatohepatitis (NASH) and liver cancer Our drug target is β-Spectrin (SPTBN1), a key player in both steatosis and fibrosis. Preclinical findings in mice (in vivo) and human 3D culture NASH model system have shown success in reducing body fat and lowering blood triacyl glycerol leves. Critically, siRNA therapies are already approved for diseases of the liver, blazing a trail for navigating regulatory approval.
Nearly 1.6 million Americans have Type 1 Diabetes (T1D), an autoimmune class of diabetes. Additionally, ~3.2 million Americans develop latent autoimmune diabetes of adults (LADA). For T1D or LADA patients, immunotherapy promises a path to reprogram the immune system such that it no longer attacks and destroys insulin-producing beta cells in the pancreas. SermAb Biologics is developing a monoclonal antibody therapy against serpinB13. SermAb Biologics focuses on the discovery that tissue regeneration is stimulated by blocking serpinB13 and restoring the activity of its protease target. The second advantage is that our antibody to serpinB13 suppresses inflammation, increases beta-cell proliferation, and delays the onset of diabetes. Thus, by using a single reagent that regulates the balance between serpin inhibitor and protease, we can simultaneously suppress the inflammatory response while promoting regenerative changes in the pancreas and other tissues expressing serpinB13.
As part of a portfolio of COVID-19 inspired innovations aimed at advancing RNA vaccines and tools, Stanford researchers have developed a secured, invite-only version of their popular Eterna platform for designing mRNA vaccines. Eterna is an online application that integrates RNA folding algorithms, a video game interface, and associated computational methods to revolutionize vaccine design and RNA structure prediction. The new, secured version of the platform (called EteRNA Enterprise) is able to host selected participants to work in a confidential manner on problems such as designing improved mRNA vaccines that can be translated to clinical trials by industry partners and other collaborators. The data and designs generated by Eterna users may be used to develop improved mRNA vaccines immediately for the COVID-19 pandemic.
Current clinical diagnostic methods require confirmation by invasive procedures such as a biopsy of the gut, skin, or liver, while protein marker tests are limited to few tissue types and do not detect infections. Short fragments of cell-free DNA circulate in blood, urine and other biofluids and offer an information-rich window into human physiology, with rapidly expanding applications in prenatal testing, cancer screening, organ transplant monitoring and infectious disease testing. Our research pursues technologies and applications of cell-free DNA in infectious and immune-related disease.
One of the most worrisome complications of the current global pandemic of COVID-19 is acute respiratory distress syndrome (ARDS), which is characterized by excess inflammation and fluid in the lung and has high mortality despite years of study. Research has indicated that more than 40% of the individuals hospitalized with severe COVID-19 develop ARDS and over half of those cases are fatal. A team of researchers at the University of Minnesota with decades of research knowledge surrounding lung diseases have developed a novel and promising treatment approach for ARDS utilizing Liothyronine (T3), a synthetic form of thyroid hormone that already has FDA approval. Application of T3 to injured lungs has been shown to speed fluid clearance in animal models and clinical trials are already underway to validate translation to humans suffering with ARDS.
Optic neuropathies are a group of optic nerve diseases characterized by the progressive death of RGCs and optic nerve degeneration. Optic neuropathy is the most common clinical cause of irreversible blindness. There is no effective neuroprotective treatment to prevent RGC/optic nerve degeneration. Genes involved in RGC signaling have been found to play roles in RGC/optic nerve degeneration and thus serve as potential gene therapy targets. However, before effective gene therapies can be developed a method to specifically target the RGCs is needed.
Neurodegenerative diseases are a large group of progressive and eventually fatal diseases of the central nervous system (CNS). These diseases – including Alzheimer’s disease, Parkinson’s diseases, amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), and Huntington’s disease – are taking an increasingly heavy toll on individuals and the society as the human population ages, yet they remain incurable. Evergreen seeks to develop novel therapies for several neurodegenerative diseases based on AAV-mediated gene transduction.
The scientific community is continuously trying to improve their understanding of genetic mechanisms in biological systems and finding biomarkers for diagnosis, prognosis and treatment. With growing accessibility, still, only the minority of investigators in the life and medical sciences has the means to analyze and leverage this enormous treasure of data. Bioada is an integrated, easy to use and interactive genomics data analysis platform for the broader community of life scientists.
Conventional electronic devices based on flexible or rigid printed circuit boards (PCBs) cannot conform to curved surfaces or stretch to accommodate new requirements of disruptive technologies. Additionally, existing methods for the production of stretchable electronics are unable to produce devices with high integration densities achievable with conventional methods. These methods also rely on processes that cannot be implemented at scale. This technology overcomes these limitations and enables practical applications of stretchable electronic devices for health monitoring, wearable computing, medical devices, and beyond.
VDIs cannot protect sensitive data unless remote users can securely operate the VDI client on their computers. If users’ computers are compromised, hackers can screen capture and view confidential data on VDI servers, and sniffer users’ keystrokes (e.g., passwords), etc. Attackers gain same VDI data access as users despite perfect network and VDI server security. Most existing products are insecure, because they assume commodity OSes (e.g., Windows 10, Mac OS) and applications have no security flaws. Other products violate users’ experiences as they cannot run user-chosen applications locally to process insensitive data. In short, no usable secure VDI client exists to-date. We built *the only usable secure VDI client*. Our on-demand isolation technique protects users’ operations even when OS and users’ locally installed tools are compromised, and maintains users’ experience. Also, our solution eliminates IT admin labor to maintain VDI client security.
Our ultimate goal is to develop novel small molecule, broad-spectrum therapeutics against viral infections caused by filoviruses, arenaviruses, rhabdoviruses, and others that depend on the PPxY L-domain motif for virus egress and spread of infection. Some of these viruses, including Ebola (EBOV), Marburg (MARV), and Lassa fever (LAFV) viruses, are highly pathogenic and classified as Category A, bioterror pathogens. Importantly, we have identified an analog capable of blocking in vivo activity in a Marburg virus challenged mouse model, providing essential proof of concept for this novel class of anti-viral therapeutics. We predict that the novel class of anti-viral products targeting EBOV, MARV, and LAFV will be used for treatment of infected individuals as well as in prophylactic treatment of soldiers, healthcare workers, or others at high risk. Emergency administration of such an antiviral therapeutic during an outbreak could potentially inhibit virus dissemination in infected individuals.
We treat faces as if they were feet, and that’s absurd. Unlike feet, faces are 3D, yet we still measure them using 2D objects such as paper cutouts in the massive $6b market to fit people with masks. This doesn’t cut it, and the data backs it up: 50% of Americans don’t wear the CPAP masks they’ve been prescribed because of these fit, comfort, and convenience issues. The only reason we’ve tolerated this is that until recently there has been no better way to get good 3d measurements of your face without lots of specialized tools. We solve this problem by making it as easy as taking a selfie to get precise 3D measurements of your face.
Dr. Xiaoyang Zhu’s research team at Columbia University developed a method for high-yield production of macroscopic 2D materials. The technique produces macroscopic 2D materials that are comparable in quality to microscopic monolayers formed by Scotch tape exfoliation, with the significant advantage of achieving high-yield production. This technology has potential to catalyze manufacturing of 2D materials such as graphene and transition metal dichalcogenide monolayers for use in many applications.
Seven Biosciences is a GPCR targeted drug discovery company which engineers and uses cutting-edge technology. Seven’s proprietary technology are fluorescent sensors based on any GPCR, which enables the functional visualization of the conformational change of the receptor in response to the binding of a given compound in real-time. The technology can be used for high throughput screening of compound libraries against GPCR targets, including orphan GPCRs, as well as for profiling the physiologically relevant effects of candidate molecules. Additionally, Seven’s GPCR sensors can be expressed in vivo –enabling the monitoring of compound effects at the site of action in awake behaving animals and in disease models undergoing treatment with unmatched spatial and real-time temporal resolution.
MedGyde develops ligand and antibody directed products which bind to antigens specific to various cancer subtypes. MedGyde’s pipeline includes antibodies and single-chain variable fragments which have demonstrated cytotoxic properties. The products have therapeutic as well as diagnostic applications (theranostic). MedGyde has also developed a radio-sensitization technology that targets and sensitizes cancer cells. The lead therapeutic antibody to inducible neoantigen, TIP1, binds specifically to cancer. It has been conjugated to both radiopharmaceuticals and chemotherapy which markedly improved cancer cures in pre-clinical cancer models. The planned clinical trial will be in patients with advanced non-small cell lung cancer. MedGyde has been awarded several NIH small business grants to further develop antibodies and nanoparticle drug delivery systems. Venture capital is needed for GMP manufacturing and IND enabling safety testing.
Keidar PlasmaTech aims to apply our non-invasive cold plasma device to treat brain tumors. The scientific leaders have complementary bench and clinical expertise that has enabled both understanding of the mechanisms of action of cold plasma to selectively kills cancer cells and the development of a plan to reach human patients in just 1 year.
OT Bio aims to apply our patented intranasal oxytocin therapy to treat sleep apnea and protect patients from associated heart disease. The scientific leaders have complementary bench and clinical expertise that has enabled both understanding of oxytocin's mechanisms in the brain and human studies showing improved respiratory and cardiac functions.
Nanopath has developed a platform for rapid, point-of-care biomarker purification and characterization from a patient sample. Our technology was originally developed at Dartmouth College as part of our PhD research, and is using advances in bioengineering and nanotechnology to reduce noise and improve signal in diagnostic systems. This allows for an integrated system that takes a complex patient sample, isolates key biomarkers, and analyses them without the need for lengthy clinical workflows. We believe that this new diagnostic paradigm has applications to a range of disease indications including bloodstream infections, cancer liquid biopsy, urinary tract infections, respiratory infections, and wound infections.
Long gap peripheral nerve injuries (i.e., gaps >3cm) remain a clinical challenge. When there is a long gap nerve injury, the standard of care is transplanting a nerve from one place in the body to the area where the defect is, a technique known as autografting. The use of an autograft requires a second surgical site resulting in longer operating times, and typically a sensory nerve is used to replace a motor/sensory nerve, which leaves an area of the body with permanent numbness. There are a handful of nerve guides on the market available to regenerate nerve gaps less than 1 inch. However, there are no synthetic guides available having an FDA-approved indication for use in nerve gaps greater than one inch. Our patented technology utilizes a biodegradable tube containing a controlled drug delivery system supplying the cues necessary to promote the growth of nerves over large gaps, thus fulfilling this clinical unmet need.
Stork.ai is leveraging its strong foundations in reproductive medicine, big data, and artificial intelligence to create next-generation fertility products that ultimately help people have babies. It is commercializing a decision assessment tool comprised of patent-pending, AI-based software (“STORK”) that reliably assesses embryo (blastocyst) quality. STORK was developed using a proprietary, multi-focal embryo image dataset from Weill Cornell’s Center for Reproductive Medicine. STORK can also predict genetic defects such as aneuploidy, which involves an abnormal number of chromosomes in the embryo.