Phasis Biotech is a privately held biotechnology company, founded to develop the work of Cliff Brangwynne, a key architect of a new paradigm of intracellular organization through liquid-liquid phase separation (LLPS), which has deep implications for aggregation diseases. Phasis employs a novel set of technologies that use light to control phase separation and protein aggregation. These technologies are adaptable and can be applied to a wide range of systems. The initial focus is on developing these technologies into a platform for screening small molecules for their ability to disrupt aggregated protein phases associated with neurodegenerative diseases. The LLPS process plays a central role in devastating and currently untreatable diseases including Alzheimer’s and ALS.
The invention details a new method for producing large quantities of diverse, functional, naïve autologous T cells for infusion into patients. The in vivo generated T cells arise from bone marrow stem cells taken from the patient and become genetically compatible immune cells that are tolerant of the patient and any selected transplant donor. With additional techniques done before collection and transfer, the T cells could also be made to recognize specific targets, altered to resist viruses (e.g. HIV resistance) or directed to become regulatory T cells that may ameliorate autoimmune disease and prevent/treat rejection of transplanted tissues. This technique could address problems such as T-cell exhaustion from cancer patients and the limitations of Ex-vivo expansion of the T-cells.
Many skin care products are damaging to the environment and potentially the consumer as well. Non-biodegradable cosmetics, especially those with plastic particles, can end up damaging aquatic life. The rising trend of environmental consciousness in consumers and regulations emphasizes the need for responsible products. Prisili products use natural materials and flash nanoprecipitation to encapsulate all natural and environmentally friendly skin care products.
Andluca Technologies designs transparent, thin-film power sources that convert ultraviolet light into useful energy at the point of use. These flexible power sources can conform to any shape and disappear into their environment to enable discreet, wireless operation of smart glass. Beyond buildings, our technologies are unlocking new functionalities in the automobile, aviation, military, eyewear, health and IoT sectors. Andluca Technologies was established in 2017 following over 12 years of research on light-responsive films by Professor Lynn Loo and her team at the Organic and Polymer Electronics Laboratory at Princeton University.
Tendo Technologies, founded in 2017, is a spin-off from the Marcus Hultmark research lab at Princeton developing a novel flow sensing/measurement technology. This unique technology achieves extreme sensitivity (for both gases and liquids) through the nanoscale conductive ribbons that will deflect when placed in flow. The nanoribbons are manufactured with standard semiconductor-based techniques, resulting in high scalability and low unit cost for the sensing chip. As a highly versatile technology (flow measurement is ubiquitous), Tendo envisions that their tech can be applied in many industries for various applications, when equipped with appropriate "wrappers" around it. For example, the Tendo chip plus communication package would be appropriate for IoT applications such as real time air measurement in HVAC ducts; alternatively, more sophisticated housing with control would bring benefits for flow metering and control during industry manufacturing processes.
With an alarming rate of high profile cyber security breaches each year, individuals and organizations are actively seeking solutions that protect their privacy and keep their data secure. Unfortunately, the most secure options such as Virtual Desktop Infrastructure (VDI) on a server is still insecure due to user errors and management overhead is inherent in current models. TigerStone's Nimble Computing Infrastructure (NCI) achieves new levels of maintainability, security, and user experience for all systems by bringing the merits of virtualization to all computers.