Overview DNA methylation-based biomarkers have great potential to transform the diagnosis, monitoring, and treatment of cancer and other diseases. DNA methylation is an epigenetic mechanism used by cells to control gene expression. During DNA methylation, methyl groups are added to the DNA molecule, changing the DNA activity but not the sequence. Errors in methylation have been linked to a variety of diseases. Currently, clinicians use DNA methylation tests to screen for certain genetic changes that can affect processes such as methionine metabolism and hormone balance. Market Opportunity Few DNA methylation-based biomarkers have been successfully translated into clinical practice. There is limited technology to assess epigenetic information cost effectively at a large scale. Leukocytes, or white blood cells, mount the immune response to pathogens and foreign antigens. Until now, the distribution of leukocytes has been determined by examination under a microscope or with a flow cytometer.