MedGyde

Washington University in St. Louis

MedGyde develops ligand and antibody directed products which bind to antigens specific to various cancer subtypes. MedGyde’s pipeline includes antibodies and single-chain variable fragments which have demonstrated cytotoxic properties. The products have therapeutic as well as diagnostic applications (theranostic). MedGyde has also developed a radio-sensitization technology that targets and sensitizes cancer cells. The lead therapeutic antibody to inducible neoantigen, TIP1, binds specifically to cancer. It has been conjugated to both radiopharmaceuticals and chemotherapy which markedly improved cancer cures in pre-clinical cancer models. The planned clinical trial will be in patients with advanced non-small cell lung cancer. MedGyde has been awarded several NIH small business grants to further develop antibodies and nanoparticle drug delivery systems. Venture capital is needed for GMP manufacturing and IND enabling safety testing.

Prostate DHI

Washington University in St. Louis

Non-invasive, accurate diagnosis and monitoring of prostate cancer through diffusion histology imaging. The technique has been validated with patient samples, demonstrates >95% agreement with pathologist-identified tumor stages, and can distinguish protest cancer from prostatitis or benign prostatic hyperplasia.

SimpEL

Washington University in St. Louis

An implantable, bone-anchored sympathetic nerve stimulator that can be used for treatment of chronic pain, hypertension, asthma, hyperactive bladder, and many other conditions.

Rotoscope

Washington University in St. Louis

In endoscopic surgery, the surgeon often has to remove the endoscope and clean the lens in order to fully visualize the surgical procedure. This wastes time and puts the patient at risk. The rotoscope is a self-cleaning endoscope which minimizes surgical time and risk to the patient.

Adhesive-coated Sutures

Washington University in St. Louis

Coated sutures are designed for improved mechanical resilience to prevent failure of surgical repair. Unlike conventional sutures, which concentrate stress at the point of attachment, these sutures use an adhesive coating and soft adhesive zone to distribute stress along the length of the suture and reinstate load transfer across the tendon‐to‐bone repair.

Venohood

Washington University in St. Louis

Venohood is a custom cuff attachment to the venous end of an arteriovenous graft that reduces graft failure by lowering rate of thrombosis at the venous anastomosis. Venohood is founded by Prof. Mohamed Zayed, the co-founder and CMO of Caeli Vascular. Dr. Zayed is a rising star in fostering innovation at Washington University in St. Louis, with 8 new medtech inventions over the past 3 years. His disclosures have lead to four patent filings and one license to his startup, Caeli.

AIFEN

Washington University in St. Louis

AIFEN is developing a two stent, fenestrated aorto-iliac endograft system for repairs in atherosclerotic occlusive diseases. AIFEN is founded by Prof. Mohamed Zayed, the co-founder and CMO of Caeli Vascular. Dr. Zayed is a rising star in fostering innovation at Washington University in St. Louis, with 8 new medtech inventions over the past 3 years. His disclosures have lead to four patent filings and one license to his startup, Caeli.

Cellulograft

Washington University in St. Louis

Cellulograft is developing an implantable device for cell replacement therapy that protects cells from immune attack. Cellulograft is founded by Prof. Mohamed Zayed, the co-founder and CMO of Caeli Vascular. Dr. Zayed is a rising star in fostering innovation at Washington University in St. Louis, with 8 new medtech inventions over the past 3 years. His disclosures have lead to four patent filings and one license to his startup, Caeli.

VaxNewMo

Washington University in St. Louis

VaxNewMo’s goal is to be the next bioconjugate vaccine platform company. It is seeking a business co-founder to help shape a clinical development, fundraising, and partnership strategy that can maximize its impact and value

Gateway Biotechnology

Washington University in St. Louis

Gateway is an emerging privately held start - up addressing hearing loss and tinnitus. Incubated with BioGenerator in St. Louis, Gateway builds on research and clinical collaborations across several academic institutions including Washington University, Northeast Ohio Medical University and Harvard University. Its founders are scientific and clinical leaders in the field. Gateway has built a comprehensive research, discovery, and clinical development platform for new therapeutics to treat tinnitus and noise-induced hearing loss (NIHL). The platform is highly leveraged by federal funding, cumulatively some $30m of research by the scientific founder, and $12m in translational funding, including a Phase II hearing loss clinical trial funded by the U.S. Army. The Company has raised no equity capital to date.